Detailed information of TA system TA108410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3718769..3719388
• Replicon: chromosome
• Accession: NZ_CP031101
• Organism: Leclercia sp. W17

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A345CDT0
• Locus tag: DVA44_RS18465
• Protein ID: WP_032616864.1
• Coordinates: 3719170..3719388 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: DVA44_RS18460
• Protein ID: WP_114387768.1
• Coordinates: 3718769..3719161 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVA44_RS18450	3713922..3715115	+	1194	WP_103824067.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
DVA44_RS18455	3715138..3718278	+	3141	WP_103178504.1	multidrug efflux RND transporter permease subunit AcrB	-
DVA44_RS18460	3718769..3719161	+	393	WP_114387768.1	Hha toxicity modulator TomB	Antitoxin
DVA44_RS18465	3719170..3719388	+	219	WP_032616864.1	hemolysin expression modulator Hha	Toxin
DVA44_RS18470	3719654..3720118	+	465	WP_114315745.1	YlaC family protein	-
DVA44_RS18475	3720169..3720309	-	141	WP_003859006.1	type B 50S ribosomal protein L36	-
DVA44_RS18480	3720567..3722135	+	1569	WP_114387769.1	EAL domain-containing protein	-
DVA44_RS18485	3722168..3722521	-	354	WP_103824063.1	DUF1428 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8583.95 Da
• Isoelectric Point: 8.9008

>T108410 WP_032616864.1 NZ_CP031101:3719170-3719388 [Leclercia sp. W17]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Nucleotide

• Length: 219 bp

>T108410 NZ_CP031101:3719170-3719388 [Leclercia sp. W17]
ATGTCTGATAAACCATTAACCAAGACTGATTATTTGATGCGTTTGCGACGCTGTCAGTCCATTGACACCCTCGAACGCGT
CATTGAAAAAAATAAATACGAGCTTTCTGATAATGAGCTTGCGGTATTCTATTCAGCAGCCGATCATCGCCTGGCTGAAC
TTACGATGAATAAGCTGTACGATAAAATCCCAACTGCTGTATGGAAGTTTGTACGCTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15194.10 Da
• Isoelectric Point: 4.8941

>AT108410 WP_114387768.1 NZ_CP031101:3718769-3719161 [Leclercia sp. W17]
MDEYSPKRQDIAQLKFLCESLYHDCLTNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNASRANPLVSPVKIITNN

Nucleotide

• Length: 393 bp

>AT108410 NZ_CP031101:3718769-3719161 [Leclercia sp. W17]
ATGGACGAATACTCGCCCAAAAGGCAAGATATTGCACAGTTGAAATTCCTTTGTGAATCCCTGTACCATGACTGCCTGAC
CAATCTCGATGAAAGCAACCATGGCTGGGTAAATGACCCTACTTCTGCCATTAATTTGCAGTTAAACGAGTTGATTGAGC
ATATTGCTACCTTCGCGCTTAATTATAAAATTAAGTATAACGAAGATAATAAGTTGATTGAGCAGATTGACGAATACCTG
GATGACACTTTTATGTTATTCAGTAGCTACGGCATTAACACACAGGATTTACAAAAATGGCGTAAATCTGGCAATCGGCT
TTTTCGTTGTTTTGTCAATGCGAGTAGAGCTAATCCGTTAGTTTCTCCGGTTAAAATTATTACAAACAATTAG

Structures

Toxin

• AlphaFold DB: A0A345CDT0