Detailed information of TA system TA108409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 2488407..2488891
• Replicon: chromosome
• Accession: NZ_CP031101
• Organism: Leclercia sp. W17

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: DVA44_RS25550
• Protein ID: WP_139157100.1
• Coordinates: 2488751..2488891 (+)
• Length: 47 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: DVA44_RS12135
• Protein ID: WP_103824398.1
• Coordinates: 2488407..2488658 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVA44_RS12130	2483801..2487592	-	3792	WP_114388412.1	glycosyltransferase	-
DVA44_RS12135	2488407..2488658	+	252	WP_103824398.1	helix-turn-helix domain-containing protein	Antitoxin
DVA44_RS25550	2488751..2488891	+	141	WP_139157100.1	type II toxin-antitoxin system HipA family toxin	Toxin
DVA44_RS12140	2488997..2490058	+	1062	WP_114387072.1	YncE family protein	-
DVA44_RS12145	2490069..2492063	+	1995	WP_114387073.1	TonB-dependent receptor	-
DVA44_RS12150	2492197..2493378	+	1182	WP_114387074.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5081.75 Da
• Isoelectric Point: 4.5148

>T108409 WP_139157100.1 NZ_CP031101:2488751-2488891 [Leclercia sp. W17]
MKEMADRTDEVIATVRAELPADFPEQISGAIFRGLASQAARISRFD

Nucleotide

• Length: 141 bp

>T108409 NZ_CP031101:2488751-2488891 [Leclercia sp. W17]
ATGAAAGAGATGGCCGACCGCACGGATGAAGTAATCGCCACCGTCAGAGCGGAATTACCGGCGGATTTTCCGGAACAGAT
AAGCGGGGCGATTTTCCGCGGTCTGGCAAGCCAGGCGGCGAGAATAAGCCGCTTCGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9267.57 Da
• Isoelectric Point: 8.6819

>AT108409 WP_103824398.1 NZ_CP031101:2488407-2488658 [Leclercia sp. W17]
MKVTTAGALAQAVRDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILAALDLELHVVKRGSTLPDNPSWT
KEW

Nucleotide

• Length: 252 bp

>AT108409 NZ_CP031101:2488407-2488658 [Leclercia sp. W17]
ATGAAAGTAACAACGGCAGGTGCACTGGCACAGGCAGTCAGAGATCAGCGTAAGGTCAATAAGTTAACGCAATCGGAGAC
CGCTGAACAGGTTGGCATTAAACAAACTACGGTATCGGATTTCGAGAACAAACCTGAATCCACCAAGCTGGAAACCTTGT
TCAAAATTCTCGCGGCGCTGGATCTGGAACTCCATGTGGTGAAAAGAGGGTCGACGCTGCCCGATAACCCCAGCTGGACA
AAGGAGTGGTAA