Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 51240..51901 Replicon chromosome
Accession NZ_CP031101
Organism Leclercia sp. W17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DVA44_RS00255 Protein ID WP_103824282.1
Coordinates 51503..51901 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DVA44_RS00250 Protein ID WP_114385492.1
Coordinates 51240..51506 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA44_RS00220 46261..46575 - 315 WP_103824276.1 PTS sugar transporter subunit IIB -
DVA44_RS00225 46870..47817 + 948 WP_103824277.1 LacI family transcriptional regulator -
DVA44_RS00230 47854..48150 - 297 WP_114388354.1 hypothetical protein -
DVA44_RS00235 48470..48889 + 420 WP_103824278.1 GNAT family N-acetyltransferase -
DVA44_RS00240 48886..49545 - 660 WP_114385490.1 TetR/AcrR family transcriptional regulator -
DVA44_RS00245 49623..51122 + 1500 WP_114385491.1 MFS transporter -
DVA44_RS00250 51240..51506 + 267 WP_114385492.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DVA44_RS00255 51503..51901 + 399 WP_103824282.1 type II toxin-antitoxin system VapC family toxin Toxin
DVA44_RS00260 52097..52900 + 804 WP_114385493.1 lipoprotein NlpA -
DVA44_RS00265 53028..53807 + 780 WP_114385494.1 MBL fold metallo-hydrolase -
DVA44_RS00270 53833..54795 + 963 WP_114316291.1 helix-turn-helix domain-containing protein -
DVA44_RS00275 54815..55903 - 1089 WP_114316290.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14682.82 Da        Isoelectric Point: 6.6410

>T108399 WP_103824282.1 NZ_CP031101:51503-51901 [Leclercia sp. W17]
MKHMLDTNIVSHLFKRHPGVVNRMTNLKPADVCISSITEAELLYGADKKQSTRLKETIKTFLSTITIYDWDSDAAAAYGK
LRAEMETRGKVMADLDQLIAAHAISRGTTIVTNDHAFGMVQELTIEDWTTAA

Download         Length: 399 bp

>T108399 NZ_CP031101:51503-51901 [Leclercia sp. W17]
ATGAAACATATGCTGGATACGAATATTGTGAGCCATTTATTTAAAAGGCATCCCGGTGTTGTAAATAGAATGACTAACCT
GAAGCCAGCGGACGTATGTATCTCAAGTATCACAGAAGCGGAGCTGCTTTATGGGGCGGATAAAAAACAAAGCACCAGGT
TAAAAGAGACCATAAAGACGTTTCTGAGCACTATCACTATCTATGACTGGGACAGTGACGCCGCAGCCGCTTACGGCAAA
CTCCGTGCTGAGATGGAAACTCGAGGTAAAGTGATGGCAGACCTTGATCAGTTGATCGCAGCCCATGCCATCAGCCGGGG
CACAACGATTGTGACTAACGATCATGCTTTCGGAATGGTACAGGAGTTGACTATCGAGGACTGGACTACAGCGGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10110.50 Da        Isoelectric Point: 4.8896

>AT108399 WP_114385492.1 NZ_CP031101:51240-51506 [Leclercia sp. W17]
MERKAKLFKKGLNQAVLLPAEFAFDAESVWIRRDEEGNVVLAAKPAKEKSWDEFFRMLENTTVPDSFLSPEERNQSITKR
DPLDGVQV

Download         Length: 267 bp

>AT108399 NZ_CP031101:51240-51506 [Leclercia sp. W17]
ATGGAACGTAAAGCAAAACTGTTCAAAAAAGGGCTAAACCAGGCGGTGTTACTGCCTGCTGAGTTCGCGTTTGATGCGGA
GAGTGTCTGGATCCGGCGGGATGAAGAGGGGAATGTGGTTCTGGCTGCAAAACCTGCCAAGGAAAAAAGCTGGGATGAAT
TTTTCAGGATGTTGGAAAACACCACCGTACCTGATTCATTTTTAAGTCCGGAGGAAAGAAATCAGAGTATTACAAAGAGG
GATCCTCTGGATGGAGTTCAGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References