Detailed information of TA system TA108395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 155441..155988
• Replicon: chromosome
• Accession: NZ_CP031093
• Organism: Hydrocarboniclastica marina strain soil36-7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: soil367_RS00710
• Protein ID: WP_136545951.1
• Coordinates: 155441..155743 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7FV42
• Locus tag: soil367_RS00715
• Protein ID: WP_022990189.1
• Coordinates: 155731..155988 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
soil367_RS00685	150592..151608	+	1017	WP_136545941.1	AraC family transcriptional regulator	-
soil367_RS00690	151812..152885	+	1074	WP_136545943.1	class I SAM-dependent methyltransferase	-
soil367_RS00695	153161..154462	+	1302	WP_136545945.1	IS1380 family transposase	-
soil367_RS00700	154647..154913	-	267	WP_136545947.1	DUF2442 domain-containing protein	-
soil367_RS00705	154873..155112	-	240	WP_136545949.1	DUF4160 domain-containing protein	-
soil367_RS00710	155441..155743	-	303	WP_136545951.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
soil367_RS00715	155731..155988	-	258	WP_022990189.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
soil367_RS00720	156278..157054	-	777	WP_136545953.1	hypothetical protein	-
soil367_RS00725	157135..157899	-	765	WP_136545955.1	hypothetical protein	-
soil367_RS00730	158000..158302	-	303	WP_136545957.1	antibiotic biosynthesis monooxygenase	-
soil367_RS00735	158520..158717	-	198	WP_136545959.1	hypothetical protein	-
soil367_RS00740	158720..159085	+	366	WP_136545961.1	hypothetical protein	-
soil367_RS00745	159189..159551	-	363	WP_136545962.1	type II toxin-antitoxin system RelE/ParE family toxin	-
soil367_RS00750	159551..159805	-	255	WP_136545964.1	type II toxin-antitoxin system ParD family antitoxin	-
soil367_RS00755	159982..160740	-	759	WP_136545966.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	153161..154462	1301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11534.27 Da
• Isoelectric Point: 4.4232

>T108395 WP_136545951.1 NZ_CP031093:c155743-155441 [Hydrocarboniclastica marina]
MAEVVWTEPALQELDAVAEYIALDNSAAASHLVQEVFEKTARLEEFPQSGRIPPELPNSVYRELVVPPCRLFYRQDEQRI
LVLCVMREERQLRAYMLGIS

Nucleotide

• Length: 303 bp

>T108395 NZ_CP031093:c155743-155441 [Hydrocarboniclastica marina]
ATGGCTGAAGTAGTCTGGACGGAGCCCGCACTTCAAGAGTTGGATGCCGTGGCCGAGTATATTGCTCTGGATAATTCTGC
TGCCGCCAGTCATCTAGTCCAGGAAGTTTTCGAGAAGACCGCGCGTTTGGAGGAATTCCCCCAATCCGGACGGATTCCTC
CGGAACTTCCCAACTCGGTTTACAGGGAGTTAGTGGTTCCACCGTGTCGCCTATTTTATCGTCAGGATGAGCAGCGGATT
CTCGTCCTTTGTGTCATGCGCGAGGAGCGGCAGCTTCGAGCGTACATGCTTGGGATCAGCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9887.41 Da
• Isoelectric Point: 8.5042

>AT108395 WP_022990189.1 NZ_CP031093:c155988-155731 [Hydrocarboniclastica marina]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT108395 NZ_CP031093:c155988-155731 [Hydrocarboniclastica marina]
ATGAAAGTTGAGCTTGTTACAAACCTCAAGCGCCAAGCCACAAAAATCCTGGCAGACCTGCATCTGTCTAAAGAGCCAGT
ACTGATCACTGAACATGGCCAGCCATCGGCTTATCTTGTTGATGTGCAGGATTACGAATTCATGCAGCGTCGACTTGAGC
TGCTTGAGGGGCTCTCACGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGCCAGAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1I1I6C4