Detailed information of TA system TA108393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1975..2497
• Replicon: plasmid pYEE7
• Accession: NZ_CP031085
• Organism: Paracoccus yeei strain CCUG 32053

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PY32053_RS22835
• Protein ID: WP_120445333.1
• Coordinates: 2213..2497 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PY32053_RS22830
• Protein ID: WP_120445332.1
• Coordinates: 1975..2223 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PY32053_RS22825	683..1114	+	432	WP_088239211.1	helix-turn-helix domain-containing protein	-
PY32053_RS23115	1176..1628	+	453	WP_147405631.1	hypothetical protein	-
PY32053_RS22830	1975..2223	+	249	WP_120445332.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PY32053_RS22835	2213..2497	+	285	WP_120445333.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PY32053_RS23120	2719..3474	-	756	WP_147405633.1	hypothetical protein	-
PY32053_RS22840	3630..4399	-	770	Protein_5	IS5 family transposase	-
PY32053_RS23125	4881..5660	-	780	WP_147405634.1	hypothetical protein	-
PY32053_RS22845	5660..6481	-	822	WP_158595062.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9652	9652

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10895.55 Da
• Isoelectric Point: 11.1450

>T108393 WP_120445333.1 NZ_CP031085:2213-2497 [Paracoccus yeei]
MTYSLRFREEAKKEWDALGATIRAQFKKKLAERLENPHVPSARLHGSANRYKIKLRAVGYRLVYEVRDAELVVSVIAVGR
RNRNAVYRDAASRH

Nucleotide

• Length: 285 bp

>T108393 NZ_CP031085:2213-2497 [Paracoccus yeei]
ATGACCTATAGCCTCCGCTTCCGCGAAGAAGCCAAGAAAGAATGGGACGCCCTGGGGGCGACGATCCGCGCGCAGTTCAA
GAAAAAGCTGGCCGAGCGGCTGGAAAACCCGCATGTGCCTTCCGCCCGCCTGCATGGCTCCGCCAATCGCTACAAGATCA
AGCTGCGGGCGGTCGGCTACCGCTTGGTCTACGAGGTGCGGGACGCGGAACTGGTGGTCAGCGTGATCGCCGTGGGGCGG
CGGAACCGGAACGCTGTCTATCGGGACGCCGCCAGCCGGCATTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8622.73 Da
• Isoelectric Point: 4.1933

>AT108393 WP_120445332.1 NZ_CP031085:1975-2223 [Paracoccus yeei]
MAHTIHAHVTASVTELKRNPMGTMAAGNGGAVAILNRNEPAFYCVPADEYEAMLTLIEDAELNALADARAASPEIAVSLD
DL

Nucleotide

• Length: 249 bp

>AT108393 NZ_CP031085:1975-2223 [Paracoccus yeei]
ATGGCGCACACCATCCATGCCCACGTGACCGCCAGTGTTACTGAGCTAAAGCGCAACCCGATGGGCACCATGGCCGCCGG
CAACGGTGGGGCCGTGGCGATCCTGAATCGCAACGAACCGGCCTTCTATTGCGTCCCGGCTGACGAGTACGAGGCGATGC
TGACCCTGATCGAGGATGCGGAACTGAACGCTCTCGCCGATGCTCGCGCCGCCAGTCCCGAAATCGCGGTCAGCCTGGAT
GACCTATAG