Detailed information of TA system TA108392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 36829..37390
• Replicon: plasmid pYEE5
• Accession: NZ_CP031083
• Organism: Paracoccus yeei strain CCUG 32053

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PY32053_RS22535
• Protein ID: WP_120445305.1
• Coordinates: 36829..37104 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PY32053_RS22540
• Protein ID: WP_080623172.1
• Coordinates: 37097..37390 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PY32053_RS23400	31855..32022	+	168	WP_158595053.1	hypothetical protein	-
PY32053_RS23110	32303..32959	-	657	WP_147405621.1	hypothetical protein	-
PY32053_RS22520	32959..33678	-	720	WP_080623169.1	hypothetical protein	-
PY32053_RS22525	34443..34991	+	549	WP_158595054.1	plasmid mobilization relaxosome protein MobC	-
PY32053_RS22530	34984..36783	+	1800	WP_147405623.1	relaxase/mobilization nuclease domain-containing protein	-
PY32053_RS22535	36829..37104	-	276	WP_120445305.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PY32053_RS22540	37097..37390	-	294	WP_080623172.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PY32053_RS22545	37503..39614	-	2112	WP_147405624.1	type IV secretory system conjugative DNA transfer family protein	-
PY32053_RS22550	39562..40551	-	990	WP_120445260.1	Flp pilus assembly complex ATPase component TadA	-
PY32053_RS22555	40551..41852	-	1302	WP_158595055.1	TrbI/VirB10 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74143	74143

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10204.87 Da
• Isoelectric Point: 6.4575

>T108392 WP_120445305.1 NZ_CP031083:c37104-36829 [Paracoccus yeei]
VPEIEWREPAVADLMAIVDYISDDNPRAALALMDEIQTKVAQLADHPKRCRPGRVAGTRELIVRPNYLVVYAETAAKVTV
LRVLHAAQMWP

Nucleotide

• Length: 276 bp

>T108392 NZ_CP031083:c37104-36829 [Paracoccus yeei]
GTGCCTGAAATCGAATGGAGAGAACCGGCGGTTGCGGACCTGATGGCGATTGTCGATTACATCTCGGATGACAATCCCCG
CGCAGCCTTGGCCTTGATGGATGAGATCCAGACTAAGGTCGCGCAACTGGCGGACCATCCGAAACGCTGCCGCCCCGGCA
GGGTGGCAGGCACGCGGGAGCTGATCGTCAGGCCGAACTACCTTGTTGTCTATGCCGAAACTGCGGCTAAGGTCACCGTT
CTGCGTGTTCTTCACGCCGCACAGATGTGGCCGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10310.88 Da
• Isoelectric Point: 9.9916

>AT108392 WP_080623172.1 NZ_CP031083:c37390-37097 [Paracoccus yeei]
MPARTAMLHVRVDSQLKTQATDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTAAPDAYDAWFRAKVQEALSDPRPGKPH
DQVVLEARALIDAKRRA

Nucleotide

• Length: 294 bp

>AT108392 NZ_CP031083:c37390-37097 [Paracoccus yeei]
ATGCCGGCACGGACCGCGATGCTCCACGTTCGCGTGGACAGCCAGCTCAAGACACAAGCGACAGACGCCCTGGCCGGGGT
GGGATTAACGCTGTCCGATGCCGTACGCATTCTGCTGACCCGGGTTGCCGCTGAAGGCGGGCTGCCAGCGGGCCTCACCG
CGGCGCCAGACGCCTATGACGCCTGGTTTCGGGCCAAGGTGCAGGAAGCGCTGAGCGATCCACGCCCCGGAAAGCCGCAT
GATCAGGTTGTCTTGGAAGCGCGCGCGCTGATCGATGCAAAACGCCGTGCCTGA