Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-copA/ParE-RHH
Location 22553..23115 Replicon plasmid pYEE5
Accession NZ_CP031083
Organism Paracoccus yeei strain CCUG 32053

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PY32053_RS22475 Protein ID WP_120445246.1
Coordinates 22553..22846 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID -
Locus tag PY32053_RS22480 Protein ID WP_120445247.1
Coordinates 22834..23115 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY32053_RS22450 17961..18584 + 624 WP_120445237.1 isoprenylcysteine carboxylmethyltransferase family protein -
PY32053_RS22455 18581..19057 + 477 WP_120445238.1 signal peptidase II -
PY32053_RS22460 19103..19555 - 453 WP_120445240.1 manganese-binding transcriptional regulator MntR -
PY32053_RS22465 19653..20975 + 1323 WP_120445242.1 Nramp family divalent metal transporter -
PY32053_RS22470 21141..22226 - 1086 WP_120445244.1 DUF475 domain-containing protein -
PY32053_RS22475 22553..22846 - 294 WP_120445246.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PY32053_RS22480 22834..23115 - 282 WP_120445247.1 ribbon-helix-helix protein, CopG family Antitoxin
PY32053_RS22485 23654..24235 + 582 WP_120445249.1 recombinase family protein -
PY32053_RS22495 24671..25930 + 1260 WP_147405617.1 AAA family ATPase -
PY32053_RS23105 25927..26970 + 1044 WP_147405619.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74143 74143
- flank IS/Tn - - 23654..24235 581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-43)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10935.60 Da        Isoelectric Point: 8.0181

>T108391 WP_120445246.1 NZ_CP031083:c22846-22553 [Paracoccus yeei]
MPQLIWTPEALQGVQRCYRFLAPKNPEAAARAVRAIREGMQIVSAHPGVGRPADKLEPAFREWLIPFGDSGYVVLYRVDD
DLAVVLAVRHQREAGYY

Download         Length: 294 bp

>T108391 NZ_CP031083:c22846-22553 [Paracoccus yeei]
ATGCCACAACTGATCTGGACGCCAGAGGCGCTGCAGGGTGTCCAGCGATGTTATCGCTTTCTTGCGCCGAAGAACCCTGA
AGCGGCAGCCCGTGCTGTGCGCGCAATCCGCGAGGGGATGCAGATCGTGTCCGCGCATCCGGGAGTCGGTCGTCCGGCCG
ACAAGTTGGAGCCGGCTTTTCGGGAATGGCTGATCCCGTTCGGGGATAGCGGCTATGTCGTTCTTTACCGTGTCGATGAT
GATCTGGCCGTTGTTCTGGCAGTCAGGCATCAGCGCGAAGCCGGGTATTATTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10643.81 Da        Isoelectric Point: 5.8328

>AT108391 WP_120445247.1 NZ_CP031083:c23115-22834 [Paracoccus yeei]
MSAHPVAVKLDADVHARVRELAKAQHRSPHYLMREAIAQYVEREEKREAFRQEALTAWATYQTSGLHVTHTEADDWLAQL
EAGQDVEPPECHN

Download         Length: 282 bp

>AT108391 NZ_CP031083:c23115-22834 [Paracoccus yeei]
ATGTCTGCTCACCCTGTTGCTGTGAAGCTGGACGCAGATGTTCATGCCCGTGTGCGGGAGCTTGCCAAGGCACAACACCG
TTCTCCCCATTACCTGATGCGTGAAGCCATTGCCCAATACGTCGAGCGCGAAGAAAAACGCGAAGCATTCCGACAAGAGG
CTCTGACAGCTTGGGCGACCTATCAGACTTCGGGCCTGCATGTGACACATACGGAGGCTGACGACTGGCTGGCGCAGCTT
GAGGCCGGGCAGGACGTGGAACCGCCTGAATGCCACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References