Detailed information of TA system TA108390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 93266..93937
• Replicon: plasmid pYEE2
• Accession: NZ_CP031080
• Organism: Paracoccus yeei strain CCUG 32053

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PY32053_RS19525
• Protein ID: WP_120444429.1
• Coordinates: 93521..93937 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A386UT90
• Locus tag: PY32053_RS19520
• Protein ID: WP_028720781.1
• Coordinates: 93266..93520 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PY32053_RS19505	88408..90420	-	2013	WP_120444425.1	cytochrome o ubiquinol oxidase subunit I	-
PY32053_RS19510	90433..91638	-	1206	WP_105291399.1	ubiquinol oxidase subunit II	-
PY32053_RS19515	91845..93152	+	1308	WP_120444427.1	MFS transporter	-
PY32053_RS19520	93266..93520	+	255	WP_028720781.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PY32053_RS19525	93521..93937	+	417	WP_120444429.1	type II toxin-antitoxin system VapC family toxin	Toxin
PY32053_RS19530	94084..95472	+	1389	WP_120444431.1	L-cystine transporter	-
PY32053_RS19535	95541..95936	+	396	WP_028720783.1	acyl-CoA thioesterase	-
PY32053_RS19540	95956..97239	-	1284	WP_120444434.1	lytic murein transglycosylase	-
PY32053_RS19545	97316..98320	-	1005	WP_120444436.1	GTP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..296393	296393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-51)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14790.89 Da
• Isoelectric Point: 5.6832

>T108390 WP_120444429.1 NZ_CP031080:93521-93937 [Paracoccus yeei]
MLILDTNVLSALRRPERSPAVAAWLARQDDTALYLSVVTLGEIERGIVRQESQNPPFARDLRAWLTRTVTLFSDRLLPFG
AAEALLWGQLSARLGHAGADLLIAATALAHDAAVVTGNTADFQPTGCRLVDPFAQGAG

Nucleotide

• Length: 417 bp

>T108390 NZ_CP031080:93521-93937 [Paracoccus yeei]
ATGCTGATCCTGGATACCAATGTCCTGTCGGCGCTGCGCCGCCCCGAACGCAGCCCGGCGGTCGCCGCCTGGCTGGCCCG
GCAGGACGACACCGCGCTCTATCTCTCCGTCGTCACCCTGGGCGAGATCGAGCGCGGCATCGTCCGCCAGGAATCGCAGA
ACCCGCCCTTTGCCCGCGACCTGCGCGCCTGGCTGACGCGCACCGTCACGCTGTTTTCCGACCGCCTGCTGCCCTTCGGC
GCGGCCGAGGCGCTGCTCTGGGGCCAGCTTTCCGCCCGGCTGGGCCACGCCGGGGCCGACTTGCTGATCGCGGCGACCGC
GCTTGCGCATGACGCGGCCGTGGTCACCGGCAACACCGCCGATTTCCAGCCGACCGGCTGCCGGCTGGTCGATCCCTTCG
CGCAAGGGGCCGGATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8936.15 Da
• Isoelectric Point: 10.8056

>AT108390 WP_028720781.1 NZ_CP031080:93266-93520 [Paracoccus yeei]
MWTLQDAKNRFSAVVDAALAGQPQQVTRRGKPAVVVLAAADYARMLAATQENRGSFAAHLLSFPGPDLGPDSGRARVAPR
DVSF

Nucleotide

• Length: 255 bp

>AT108390 NZ_CP031080:93266-93520 [Paracoccus yeei]
ATGTGGACGCTTCAGGATGCCAAGAACCGCTTTTCGGCCGTGGTCGATGCGGCGCTCGCCGGCCAGCCGCAACAGGTGAC
GCGGCGCGGCAAGCCCGCCGTCGTGGTGCTGGCCGCCGCGGATTACGCCCGGATGCTGGCCGCGACGCAGGAAAACCGCG
GCTCCTTCGCCGCCCATCTCCTCAGCTTTCCGGGCCCCGACCTGGGCCCCGATTCCGGGCGCGCCCGGGTGGCCCCGCGC
GACGTCAGCTTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A386UT90