Detailed information of TA system TA108389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 1867130..1867662
• Replicon: chromosome
• Accession: NZ_CP031078
• Organism: Paracoccus yeei strain CCUG 32053

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: PY32053_RS09190
• Protein ID: WP_120441940.1
• Coordinates: 1867130..1867378 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: PY32053_RS09195
• Protein ID: WP_120441941.1
• Coordinates: 1867375..1867662 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PY32053_RS09170	1862625..1863938	+	1314	WP_120441936.1	sensor histidine kinase	-
PY32053_RS09175	1864039..1865403	+	1365	WP_120441938.1	NAD(P)-dependent oxidoreductase	-
PY32053_RS09180	1865396..1866694	+	1299	WP_028717623.1	NAD-dependent dihydropyrimidine dehydrogenase subunit PreA	-
PY32053_RS09190	1867130..1867378	+	249	WP_120441940.1	BrnT family toxin	Toxin
PY32053_RS09195	1867375..1867662	+	288	WP_120441941.1	BrnA antitoxin family protein	Antitoxin
PY32053_RS23260	1867770..1867931	-	162	WP_158594988.1	hypothetical protein	-
PY32053_RS09205	1868036..1869250	-	1215	WP_120441944.1	phage tail tape measure protein	-
PY32053_RS09210	1869380..1870312	+	933	WP_120440378.1	IS5 family transposase	-
PY32053_RS09215	1870309..1871175	-	867	WP_120441946.1	flagellin	-
PY32053_RS09220	1871340..1871654	-	315	WP_120441948.1	hypothetical protein	-
PY32053_RS09225	1871651..1871842	-	192	WP_158595011.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-78)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (20-93)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8988.43 Da
• Isoelectric Point: 6.4582

>T108389 WP_120441940.1 NZ_CP031078:1867130-1867378 [Paracoccus yeei]
MTMIVWDEPKRLTNLAKHGLDFADLDEQFFLDSVVVPAKGGRHMAIGRMSDGTIAVVFATLGTEGVSVISMRPASQKERN
LL

Nucleotide

• Length: 249 bp

>T108389 NZ_CP031078:1867130-1867378 [Paracoccus yeei]
ATGACGATGATCGTGTGGGATGAACCGAAGCGGCTGACGAACCTTGCCAAGCACGGTTTGGACTTTGCCGATCTGGATGA
ACAGTTCTTTCTGGATTCGGTCGTCGTTCCCGCAAAGGGCGGGCGTCACATGGCGATAGGCCGCATGTCCGATGGCACCA
TTGCCGTGGTGTTCGCAACGCTGGGCACCGAAGGCGTATCGGTCATTTCGATGCGGCCCGCCAGCCAAAAGGAAAGGAAT
CTGCTATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10576.01 Da
• Isoelectric Point: 10.4689

>AT108389 WP_120441941.1 NZ_CP031078:1867375-1867662 [Paracoccus yeei]
MTRKHLTEEQIQRMIASDPDAPEATDDQIAQARPFTEAFPALADAMRKNTGGRPKSANPKVAVSLRLDRDVVERFKTSGP
GWQSRMNAILRDAKV

Nucleotide

• Length: 288 bp

>AT108389 NZ_CP031078:1867375-1867662 [Paracoccus yeei]
ATGACCAGAAAGCACCTGACCGAAGAACAAATTCAACGCATGATCGCAAGCGATCCTGACGCGCCGGAAGCGACGGACGA
TCAGATTGCACAAGCGCGCCCCTTCACCGAAGCGTTCCCCGCCCTGGCCGACGCGATGCGCAAGAACACCGGCGGGCGTC
CAAAATCGGCCAACCCGAAAGTTGCCGTGTCGCTGCGGCTGGACCGGGACGTTGTGGAGCGGTTCAAAACCAGTGGCCCC
GGCTGGCAGTCCAGAATGAACGCGATTCTGCGTGACGCGAAGGTTTGA