Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1216077..1216760 Replicon chromosome
Accession NZ_CP031078
Organism Paracoccus yeei strain CCUG 32053

Toxin (Protein)


Gene name vapC Uniprot ID A0A2D2C1U7
Locus tag PY32053_RS05970 Protein ID WP_028718935.1
Coordinates 1216332..1216760 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2D2C1V4
Locus tag PY32053_RS05965 Protein ID WP_028718936.1
Coordinates 1216077..1216328 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY32053_RS05935 1212168..1212491 + 324 WP_199722303.1 transposase -
PY32053_RS05940 1212491..1213207 + 717 Protein_1181 ABC transporter ATP-binding protein -
PY32053_RS05945 1213204..1213845 + 642 WP_099649285.1 ABC transporter ATP-binding protein -
PY32053_RS05950 1213944..1214993 - 1050 WP_120441253.1 hypothetical protein -
PY32053_RS05955 1215230..1215430 + 201 Protein_1184 hypothetical protein -
PY32053_RS23515 1215626..1215868 + 243 WP_199722256.1 hypothetical protein -
PY32053_RS05960 1215865..1216023 + 159 WP_199722257.1 DUF3363 domain-containing protein -
PY32053_RS05965 1216077..1216328 + 252 WP_028718936.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PY32053_RS05970 1216332..1216760 + 429 WP_028718935.1 PIN domain-containing protein Toxin
PY32053_RS05980 1217005..1217239 + 235 Protein_1189 transposase -
PY32053_RS22975 1217263..1217673 - 411 WP_147405540.1 hypothetical protein -
PY32053_RS05985 1217766..1219832 - 2067 WP_120441255.1 AAA family ATPase -
PY32053_RS23520 1219961..1220959 - 999 WP_199722258.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-65)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15212.40 Da        Isoelectric Point: 6.9897

>T108388 WP_028718935.1 NZ_CP031078:1216332-1216760 [Paracoccus yeei]
MYLLDTNIVSASAPTRRDADVLAAWMRAHSDRLYLSAITIAEIEAGIARAVRIGASSKAPALRRWLAAVEHFYASRILAF
GIEEARQAGAILDQARAHDPGFEDIAIAATAAAHGLTVLTANERHFAPLGVPYANPLKELPA

Download         Length: 429 bp

>T108388 NZ_CP031078:1216332-1216760 [Paracoccus yeei]
TTGTACCTGCTCGATACCAACATCGTTTCGGCCTCCGCGCCGACGAGGCGAGACGCCGATGTTCTCGCTGCATGGATGCG
CGCCCACAGCGACCGGCTCTATCTCTCGGCCATCACCATCGCCGAGATCGAGGCCGGCATCGCCCGGGCGGTCAGGATCG
GCGCCAGCAGCAAGGCCCCGGCGCTGCGCCGCTGGCTCGCTGCGGTCGAGCATTTCTACGCCAGCCGGATCCTCGCTTTC
GGCATCGAGGAGGCTCGTCAGGCCGGGGCGATCCTCGACCAGGCGCGTGCCCATGATCCGGGCTTCGAGGACATCGCCAT
CGCGGCGACGGCTGCCGCGCATGGCCTGACGGTGCTGACCGCCAACGAGCGGCATTTCGCGCCGCTCGGCGTGCCCTATG
CAAATCCGTTGAAGGAACTGCCCGCATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9337.72 Da        Isoelectric Point: 7.0152

>AT108388 WP_028718936.1 NZ_CP031078:1216077-1216328 [Paracoccus yeei]
MKELQLRDAKATLSAVIDQAVAGEPTVITRHGRKEAVLLSFEEWQRISRVPDFADLLLAFPGQPEDIPERTRKPARALRD
TSL

Download         Length: 252 bp

>AT108388 NZ_CP031078:1216077-1216328 [Paracoccus yeei]
ATGAAGGAACTCCAGCTCAGGGATGCGAAGGCGACGCTTTCCGCCGTGATCGATCAGGCCGTGGCGGGCGAGCCGACGGT
CATCACCCGGCACGGCCGCAAGGAGGCGGTGCTGCTCTCCTTCGAGGAATGGCAGCGCATCTCGCGAGTTCCGGATTTCG
CCGACCTGCTGCTGGCCTTTCCCGGCCAGCCGGAGGATATCCCCGAACGCACCCGCAAGCCTGCACGCGCGCTGCGGGAT
ACGAGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D2C1U7

Antitoxin

Source ID Structure
AlphaFold DB A0A2D2C1V4

References