Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2423789..2424767 Replicon chromosome
Accession NZ_CP031071
Organism Bacillus mycoides strain BPN401

Toxin (Protein)


Gene name spoIISA Uniprot ID R8N1U0
Locus tag DN409_RS12455 Protein ID WP_002032139.1
Coordinates 2423789..2424529 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID J8YSJ3
Locus tag DN409_RS12460 Protein ID WP_002069312.1
Coordinates 2424642..2424767 (+) Length 42 a.a.

Genomic Context

DN409_RS12425DN409_RS12430DN409_RS12440DN409_RS12445DN409_RS12455DN409_RS12460DN409_RS12465DN409_RS30880DN409_RS12485DN409_RS30885DN409_RS12435DN409_RS12470DN409_RS12475DN409_RS12480
Location: 2419759..2420469 (711 bp)
Type: Others
Protein ID: WP_061689428.1
Location: 2420588..2421001 (414 bp)
Type: Others
Protein ID: WP_002012925.1
Location: 2422084..2422560 (477 bp)
Type: Others
Protein ID: WP_061689429.1
Location: 2422714..2423451 (738 bp)
Type: Others
Protein ID: WP_002032137.1
Location: 2423789..2424529 (741 bp)
Type: Toxin
Protein ID: WP_002032139.1
Location: 2424642..2424767 (126 bp)
Type: Antitoxin
Protein ID: WP_002069312.1
Location: 2424843..2425019 (177 bp)
Type: Others
Protein ID: WP_002141782.1
Location: 2426217..2426393 (177 bp)
Type: Others
Protein ID: WP_002141786.1
Location: 2427110..2428579 (1470 bp)
Type: Others
Protein ID: WP_149190503.1
Location: 2428939..2429088 (150 bp)
Type: Others
Protein ID: WP_187770547.1
Location: 2421178..2421810 (633 bp)
Type: Others
Protein ID: WP_002017047.1
Location: 2425063..2425338 (276 bp)
Type: Others
Protein ID: WP_002141783.1
Location: 2425365..2425895 (531 bp)
Type: Others
Protein ID: WP_040963068.1
Location: 2426469..2426858 (390 bp)
Type: Others
Protein ID: WP_061689430.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DN409_RS124252419759..2420469+711WP_061689428.1class I SAM-dependent methyltransferase-
DN409_RS124302420588..2421001+414WP_002012925.1VOC family protein-
DN409_RS124352421178..2421810-633WP_002017047.1glutamine amidotransferase-
DN409_RS124402422084..2422560+477WP_061689429.1MarR family winged helix-turn-helix transcriptional regulator-
DN409_RS124452422714..2423451+738WP_002032137.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
DN409_RS124552423789..2424529+741WP_002032139.1type II toxin-antitoxin system SpoIISA family toxinToxin
DN409_RS124602424642..2424767+126WP_002069312.1hypothetical proteinAntitoxin
DN409_RS124652424843..2425019+177WP_002141782.1hypothetical protein-
DN409_RS124702425063..2425338-276WP_002141783.1hypothetical protein-
DN409_RS124752425365..2425895-531WP_040963068.1hypothetical protein-
DN409_RS308802426217..2426393+177WP_002141786.1hypothetical protein-
DN409_RS124802426469..2426858-390WP_061689430.1YxeA family protein-
DN409_RS124852427110..2428579+1470WP_149190503.1aminoacyl-histidine dipeptidase-
DN409_RS308852428939..2429088+150WP_187770547.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28482.11 Da        Isoelectric Point: 8.3034

>T108387 WP_002032139.1 NZ_CP031071:2423789-2424529 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T108387 NZ_CP031071:2423789-2424529 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ACGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4937.36 Da        Isoelectric Point: 3.9798

>AT108387 WP_002069312.1 NZ_CP031071:2424642-2424767 [Bacillus mycoides]
VIKDYDNDFFKENNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT108387 NZ_CP031071:2424642-2424767 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAAATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBR8N1U0

Antitoxin

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Source
ID
Structure
AlphaFold DBJ8YSJ3

References