Detailed information of TA system TA108383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2264447..2265425
• Replicon: chromosome
• Accession: NZ_CP031065
• Organism: Bacillus sp. SH8-8

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: DN405_RS11775
• Protein ID: WP_149149580.1
• Coordinates: 2264447..2265184 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: DN405_RS11780
• Protein ID: WP_000237818.1
• Coordinates: 2265297..2265425 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DN405_RS11755	2260099..2260871	+	773	Protein_2197	class I SAM-dependent methyltransferase	-
DN405_RS11760	2261029..2262714	-	1686	WP_149149579.1	alpha-keto acid decarboxylase family protein	-
DN405_RS11765	2262822..2263304	+	483	WP_000191886.1	MarR family winged helix-turn-helix transcriptional regulator	-
DN405_RS11770	2263471..2264208	+	738	WP_000594152.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
DN405_RS11775	2264447..2265184	+	738	WP_149149580.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
DN405_RS11780	2265297..2265425	+	129	WP_000237818.1	hypothetical protein	Antitoxin
DN405_RS11785	2265498..2265674	+	177	WP_065382523.1	stage II sporulation protein SB	-
DN405_RS11790	2265751..2266083	-	333	WP_149149581.1	YxeA family protein	-
DN405_RS11795	2266295..2267764	+	1470	WP_000287539.1	beta-Ala-His dipeptidase	-
DN405_RS11800	2268010..2268819	+	810	WP_000664544.1	C39 family peptidase	-
DN405_RS11805	2268845..2269447	+	603	WP_149149582.1	hypothetical protein	-
DN405_RS11810	2269691..2269942	-	252	WP_149149583.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28250.92 Da
• Isoelectric Point: 7.3941

>T108383 WP_149149580.1 NZ_CP031065:2264447-2265184 [Bacillus sp. SH8-8]
MISNIQIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T108383 NZ_CP031065:2264447-2265184 [Bacillus sp. SH8-8]
ATGATCTCTAACATTCAAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACTGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGCTATTTTTGTTGATATTGCGTTC
ATTTTAACACCTAATATTTCTGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT108383 WP_000237818.1 NZ_CP031065:2265297-2265425 [Bacillus sp. SH8-8]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT108383 NZ_CP031065:2265297-2265425 [Bacillus sp. SH8-8]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAGTCATAA

Structures

Antitoxin

• AlphaFold DB: W8YZL5