Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795259..795916 Replicon chromosome
Accession NZ_CP031061
Organism Klebsiella variicola strain GN02

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DUZ89_RS03920 Protein ID WP_002916310.1
Coordinates 795506..795916 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DUZ89_RS03915 Protein ID WP_002916312.1
Coordinates 795259..795525 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DUZ89_RS03895 791753..792481 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
DUZ89_RS03900 792532..792843 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
DUZ89_RS03905 793007..793666 + 660 WP_008806429.1 hemolysin III family protein -
DUZ89_RS03910 794030..795013 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
DUZ89_RS03915 795259..795525 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DUZ89_RS03920 795506..795916 + 411 WP_002916310.1 protein YgfX Toxin
DUZ89_RS03925 795923..796444 - 522 WP_008806427.1 flavodoxin FldB -
DUZ89_RS03930 796545..797441 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
DUZ89_RS03935 797464..798177 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DUZ89_RS03940 798183..799916 + 1734 WP_039102536.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T108366 WP_002916310.1 NZ_CP031061:795506-795916 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T108366 NZ_CP031061:795506-795916 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT108366 WP_002916312.1 NZ_CP031061:795259-795525 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT108366 NZ_CP031061:795259-795525 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References