Detailed information of TA system TA108357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 106924..108507
• Replicon: chromosome
• Accession: NZ_CP031058
• Organism: Stenotrophomonas maltophilia strain SM 866

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: DUW70_RS00460
• Protein ID: WP_189720330.1
• Coordinates: 106924..108246 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: M5CTC8
• Locus tag: DUW70_RS00465
• Protein ID: WP_004134030.1
• Coordinates: 108250..108507 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DUW70_RS00445	102553..104184	-	1632	WP_189720329.1	TldD/PmbA family protein	-
DUW70_RS00450	104739..106089	-	1351	Protein_89	IS3 family transposase	-
DUW70_RS00455	106309..106923	+	615	WP_049462868.1	DUF938 domain-containing protein	-
DUW70_RS00460	106924..108246	-	1323	WP_189720330.1	type II toxin-antitoxin system HipA family toxin	Toxin
DUW70_RS00465	108250..108507	-	258	WP_004134030.1	helix-turn-helix transcriptional regulator	Antitoxin
DUW70_RS00470	108665..112351	-	3687	WP_189720331.1	indolepyruvate ferredoxin oxidoreductase family protein	-
DUW70_RS00475	112520..113155	+	636	WP_032128715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	105697..115034	9337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48715.34 Da
• Isoelectric Point: 6.7182

>T108357 WP_189720330.1 NZ_CP031058:c108246-106924 [Stenotrophomonas maltophilia]
MGTLRVWMNGVEVALWDDARSGSSRLSYVDSWISSAQSRPLSLSLPLLPEGESHRGDVVNNYFDNLLPDNAVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAVQLLPLSHTPGDIQQITCEALDESGVAAILRQVTAGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFEDRATFFKTQILFWMLAATDGHAKNFSVYLE
AGGRFRLTPVYDVLSVHPSLGRGPNQLDPRNAQLAMSVQGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPSDFPGNVSEPIFNGLRAAAARLSSMSPDA

Nucleotide

• Length: 1323 bp

>T108357 NZ_CP031058:c108246-106924 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGCCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCACTCTCACTGCCCCTGCTCCCGGAGGGTGAGAGCC
ATCGGGGCGATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGCCGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACATTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGTGCAACTGCTGCC
GCTTTCGCATACACCAGGGGACATCCAGCAGATTACGTGCGAAGCGTTGGACGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGGCAGGGAATCTACCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCATATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTGTGCATGCAACTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTTATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGATGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCTGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCGAGGATCGGGCGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTTTACCTCGAA
GCCGGTGGACGCTTCCGCCTGACACCCGTCTACGACGTATTGTCGGTGCATCCCAGCCTGGGTAGGGGGCCAAACCAGCT
CGACCCGCGGAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAATCGCCACCGGAAGCTGCACCTTGTGCGACGACGCC
ATTGGAACGAAACCGCACGCGCCTGTGGTGTCGCTGATGGTGCGGAGCCGTGGATCGAAGCGCTGATCGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACCCGTCAGCTCCCAAGTGATTTCCCCGGAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCGGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.01 Da
• Isoelectric Point: 12.0740

>AT108357 WP_004134030.1 NZ_CP031058:c108507-108250 [Stenotrophomonas maltophilia]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVRLQQRSPPETT
STLEW

Nucleotide

• Length: 258 bp

>AT108357 NZ_CP031058:c108507-108250 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAGGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGATTGCAGCAGCGAAGCCCCCCGGAGACAACG
TCAACGTTGGAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: M5CTC8