108355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1151535..1152175 Replicon chromosome
Accession NZ_CP031057
Organism Acidipropionibacterium acidipropionici strain WGS7

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S5HP76
Locus tag DUY81_RS05010 Protein ID WP_062819382.1
Coordinates 1151535..1151927 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K7S7C8
Locus tag DUY81_RS05015 Protein ID WP_015071399.1
Coordinates 1151924..1152175 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DUY81_RS04990 1147772..1148062 - 291 WP_198401452.1 metal-sensitive transcriptional regulator -
DUY81_RS04995 1148214..1148915 + 702 WP_071001097.1 DUF3151 family protein -
DUY81_RS05000 1148976..1149842 + 867 WP_015071402.1 GNAT family N-acetyltransferase -
DUY81_RS05005 1150047..1151333 + 1287 WP_015071401.1 adenylosuccinate synthase -
DUY81_RS05010 1151535..1151927 - 393 WP_062819382.1 type II toxin-antitoxin system VapC family toxin Toxin
DUY81_RS05015 1151924..1152175 - 252 WP_015071399.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DUY81_RS05020 1152390..1153709 + 1320 WP_062820686.1 phosphoribosylamine--glycine ligase -
DUY81_RS05025 1153771..1155204 + 1434 WP_062819381.1 adenylosuccinate lyase -
DUY81_RS05030 1155307..1156239 - 933 WP_062819380.1 hydrogen peroxide-inducible genes activator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13530.30 Da        Isoelectric Point: 4.0038

>T108355 WP_062819382.1 NZ_CP031057:c1151927-1151535 [Acidipropionibacterium acidipropionici]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAA
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDAFPQTDIVVADR

Download         Length: 393 bp

>T108355 NZ_CP031057:c1151927-1151535 [Acidipropionibacterium acidipropionici]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGCT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGCCTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.56 Da        Isoelectric Point: 6.0829

>AT108355 WP_015071399.1 NZ_CP031057:c1152175-1151924 [Acidipropionibacterium acidipropionici]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Download         Length: 252 bp

>AT108355 NZ_CP031057:c1152175-1151924 [Acidipropionibacterium acidipropionici]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5HP76

Antitoxin

Source ID Structure
AlphaFold DB K7S7C8

References