Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 328448..329130 | Replicon | chromosome |
| Accession | NZ_CP031057 | ||
| Organism | Acidipropionibacterium acidipropionici strain WGS7 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | DUY81_RS01455 | Protein ID | WP_062819791.1 |
| Coordinates | 328711..329130 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | K7SF30 |
| Locus tag | DUY81_RS01450 | Protein ID | WP_015068797.1 |
| Coordinates | 328448..328711 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DUY81_RS01420 | 323663..324472 | + | 810 | WP_071001126.1 | tyrosine-protein phosphatase | - |
| DUY81_RS01425 | 324742..325599 | + | 858 | WP_062819794.1 | MFS transporter | - |
| DUY81_RS01430 | 325533..326054 | + | 522 | WP_062819793.1 | MFS transporter | - |
| DUY81_RS01435 | 326036..327328 | - | 1293 | WP_062820775.1 | ArsB/NhaD family transporter | - |
| DUY81_RS01440 | 327381..327830 | - | 450 | WP_062819792.1 | CBS domain-containing protein | - |
| DUY81_RS01445 | 328060..328326 | + | 267 | WP_015068798.1 | hypothetical protein | - |
| DUY81_RS01450 | 328448..328711 | + | 264 | WP_015068797.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| DUY81_RS01455 | 328711..329130 | + | 420 | WP_062819791.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| DUY81_RS01460 | 329293..329604 | - | 312 | WP_081685418.1 | helix-turn-helix domain-containing protein | - |
| DUY81_RS01465 | 329604..329972 | - | 369 | WP_099093033.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| DUY81_RS01475 | 330365..331282 | + | 918 | WP_082815990.1 | SDR family oxidoreductase | - |
| DUY81_RS01480 | 331444..331761 | + | 318 | WP_198401494.1 | PadR family transcriptional regulator | - |
| DUY81_RS01485 | 331761..332168 | + | 408 | WP_126133026.1 | DUF1048 domain-containing protein | - |
| DUY81_RS01490 | 332165..332968 | + | 804 | WP_062819788.1 | ATP-binding cassette domain-containing protein | - |
| DUY81_RS01495 | 332965..333726 | + | 762 | WP_062819787.1 | ABC transporter permease | - |
| DUY81_RS01500 | 333744..334127 | - | 384 | WP_015068789.1 | D-ribose pyranase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15033.29 Da Isoelectric Point: 4.9147
>T108352 WP_062819791.1 NZ_CP031057:328711-329130 [Acidipropionibacterium acidipropionici]
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVAAPGTPRNPQPNII
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVAAPGTPRNPQPNII
Download Length: 420 bp
>T108352 NZ_CP031057:328711-329130 [Acidipropionibacterium acidipropionici]
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTCGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACGGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGCCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATTTGA
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTCGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACGGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGCCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATTTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9390.67 Da Isoelectric Point: 10.3568
>AT108352 WP_015068797.1 NZ_CP031057:328448-328711 [Acidipropionibacterium acidipropionici]
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
Download Length: 264 bp
>AT108352 NZ_CP031057:328448-328711 [Acidipropionibacterium acidipropionici]
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|