Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1053545..1054119 Replicon chromosome
Accession NZ_CP031054
Organism Moorella thermoacetica strain 39073-HH

Toxin (Protein)


Gene name mazF Uniprot ID A0A0S6UGS1
Locus tag MothHH_RS05450 Protein ID WP_011392535.1
Coordinates 1053772..1054119 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D7X9U1
Locus tag MothHH_RS05445 Protein ID WP_053094734.1
Coordinates 1053545..1053778 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MothHH_RS05415 1048563..1048817 - 255 WP_011392529.1 DUF3243 domain-containing protein -
MothHH_RS05420 1049109..1049795 - 687 WP_011392530.1 manganese catalase family protein -
MothHH_RS05425 1050278..1050511 + 234 WP_139560391.1 hypothetical protein -
MothHH_RS05430 1050495..1050758 + 264 WP_011392531.1 type II toxin-antitoxin system RelE/ParE family toxin -
MothHH_RS05440 1051831..1053246 + 1416 WP_162490286.1 YdcF family protein -
MothHH_RS05445 1053545..1053778 + 234 WP_053094734.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MothHH_RS05450 1053772..1054119 + 348 WP_011392535.1 endoribonuclease MazF Toxin
MothHH_RS05455 1054470..1055999 + 1530 WP_011392536.1 YifB family Mg chelatase-like AAA ATPase -
MothHH_RS05460 1056153..1056677 + 525 WP_011392537.1 hypothetical protein -
MothHH_RS05465 1056867..1057967 + 1101 WP_011392538.1 iron-containing alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12605.71 Da        Isoelectric Point: 7.8219

>T108349 WP_011392535.1 NZ_CP031054:1053772-1054119 [Moorella thermoacetica]
MVNEMETYIPERGDIVWLQFDPRAGHEQAGRRPALVISPQLYNGKVGLALFCPVTTKAKGYPFEVEIPAGLKITGVILAD
QVKSLDWRAREAQFACKVPAGVVAEVQAKVQVLIS

Download         Length: 348 bp

>T108349 NZ_CP031054:1053772-1054119 [Moorella thermoacetica]
ATGGTAAACGAGATGGAAACCTATATTCCCGAACGTGGTGATATAGTCTGGCTCCAGTTTGATCCTCGGGCAGGACATGA
GCAAGCTGGCAGGCGGCCGGCGCTGGTAATTTCACCGCAACTTTATAACGGCAAAGTGGGACTGGCCCTTTTTTGCCCAG
TTACTACAAAGGCGAAGGGTTATCCCTTTGAAGTAGAGATACCGGCTGGTTTAAAGATTACCGGAGTGATCCTGGCAGAC
CAGGTAAAAAGCCTTGACTGGCGGGCAAGGGAGGCGCAATTTGCCTGTAAAGTCCCGGCAGGGGTGGTAGCAGAAGTCCA
GGCTAAAGTTCAGGTGTTGATTTCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8798.14 Da        Isoelectric Point: 7.2029

>AT108349 WP_053094734.1 NZ_CP031054:1053545-1053778 [Moorella thermoacetica]
MQPHVQKWGNSLGIRIPLSLAQKIGLREGTPVDLQVDEDAIIIRRKQYSLEQMLARVKPENIHSEIDTGPQVGREIW

Download         Length: 234 bp

>AT108349 NZ_CP031054:1053545-1053778 [Moorella thermoacetica]
ATGCAACCTCATGTGCAAAAGTGGGGCAATAGTTTAGGGATACGTATCCCTTTGTCGCTAGCCCAAAAAATCGGCCTTAG
AGAAGGCACACCGGTTGATTTACAGGTAGATGAGGATGCGATAATTATCCGCCGCAAACAATACAGCCTGGAACAAATGT
TAGCCCGGGTTAAACCTGAAAATATTCATAGTGAAATAGATACCGGGCCTCAGGTTGGGCGGGAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S6UGS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7X9U1

References