Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 263755..264412 Replicon chromosome
Accession NZ_CP031009
Organism Alcanivorax sp. ALC70

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ASALC70_RS01370 Protein ID WP_260549647.1
Coordinates 263755..264144 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ASALC70_RS01375 Protein ID WP_260549648.1
Coordinates 264149..264412 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASALC70_RS01360 (ASALC70_00284) 258900..260246 - 1347 WP_260549645.1 CRISPR-associated helicase Cas3' -
ASALC70_RS01365 (ASALC70_00285) 260213..261586 - 1374 WP_260549646.1 CRISPR-associated endonuclease Cas3'' -
ASALC70_RS01370 263755..264144 - 390 WP_260549647.1 type II toxin-antitoxin system VapC family toxin Toxin
ASALC70_RS01375 (ASALC70_00286) 264149..264412 - 264 WP_260549648.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ASALC70_RS01380 (ASALC70_00287) 265502..266224 - 723 WP_260549649.1 proteasome-type protease -
ASALC70_RS01385 (ASALC70_00288) 266247..266564 - 318 WP_260549650.1 transglutaminase family protein -
ASALC70_RS01390 (ASALC70_00289) 266495..267040 - 546 WP_260549651.1 transglutaminase N-terminal domain-containing protein -
ASALC70_RS01395 (ASALC70_00290) 267037..267966 - 930 WP_260549652.1 alpha-E domain-containing protein -
ASALC70_RS01400 (ASALC70_00291) 267960..269396 - 1437 WP_260549653.1 circularly permuted type 2 ATP-grasp protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

SpoVT-AbrB domain

(8-49)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13952.95 Da        Isoelectric Point: 5.7173

>T108292 WP_260549647.1 NZ_CP031009:c264144-263755 [Alcanivorax sp. ALC70]
MLDTNTVSQLLRGQPAVVAAVTATSIGELCISAVTEGELRFGLARRPGATRLAALVREFLARVSVEPWNSDVAQRYGTLR
ADNQALGVSLSDLDMMIAGHAYSLGLVLVTSDKAFRHIRGLEVEDWAER

Download         Length: 390 bp

>T108292 NZ_CP031009:c264144-263755 [Alcanivorax sp. ALC70]
ATGCTGGACACGAACACGGTGAGCCAGTTGCTGCGAGGCCAGCCCGCCGTCGTCGCGGCCGTCACGGCTACTTCAATTGG
TGAGCTCTGCATCTCGGCCGTCACCGAGGGAGAGTTGCGATTCGGACTTGCGCGTCGACCTGGCGCCACACGTCTGGCGG
CTCTGGTTCGTGAGTTCTTGGCCCGGGTGTCCGTTGAGCCTTGGAATTCCGATGTGGCGCAACGATACGGTACGCTGAGG
GCCGACAACCAGGCCCTCGGTGTATCACTGTCCGACCTGGATATGATGATCGCGGGGCATGCCTATTCGCTCGGCCTGGT
GTTGGTGACGTCGGACAAGGCATTCAGACACATTCGGGGTCTTGAAGTCGAAGATTGGGCCGAAAGGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9811.96 Da        Isoelectric Point: 4.6336

>AT108292 WP_260549648.1 NZ_CP031009:c264412-264149 [Alcanivorax sp. ALC70]
MTDTAKVFMSGRSQAVRLPAAYRFTEKEVFIRRDPVTGDIVLSPRPENWAGFLEAQARTEVPDDFLTPDDRAARDANRDP
LEGMDRG

Download         Length: 264 bp

>AT108292 NZ_CP031009:c264412-264149 [Alcanivorax sp. ALC70]
ATGACCGATACAGCAAAGGTATTCATGAGTGGGCGGAGCCAGGCAGTGCGGCTGCCGGCCGCGTATCGCTTCACTGAAAA
AGAGGTTTTCATCCGCCGGGACCCGGTAACCGGGGACATCGTGCTGAGCCCGCGTCCGGAGAACTGGGCGGGCTTCCTCG
AAGCGCAGGCCCGGACCGAGGTGCCGGATGACTTTCTGACACCGGATGACCGTGCCGCCCGCGATGCGAATCGCGACCCT
CTTGAGGGCATGGATCGTGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References