Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2295576..2296554 Replicon chromosome
Accession NZ_CP030982
Organism Bacillus cereus strain ZB201708

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag DT426_RS11785 Protein ID WP_000624981.1
Coordinates 2295576..2296313 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag DT426_RS11790 Protein ID WP_000237817.1
Coordinates 2296426..2296554 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DT426_RS11755 2291174..2291581 + 408 WP_000072495.1 VOC family protein -
DT426_RS11760 2291918..2292700 + 783 WP_000381780.1 class I SAM-dependent methyltransferase -
DT426_RS11765 2292855..2293700 - 846 Protein_2238 alpha-keto acid decarboxylase family protein -
DT426_RS11770 2293676..2293844 - 169 Protein_2239 hypothetical protein -
DT426_RS11775 2293952..2294434 + 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
DT426_RS11780 2294600..2295337 + 738 WP_098829406.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
DT426_RS11785 2295576..2296313 + 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
DT426_RS11790 2296426..2296554 + 129 WP_000237817.1 hypothetical protein Antitoxin
DT426_RS11795 2296627..2296803 + 177 WP_127725804.1 stage II sporulation protein SB -
DT426_RS11800 2296822..2297211 - 390 WP_000712655.1 YxeA family protein -
DT426_RS11805 2297423..2298892 + 1470 WP_000287540.1 beta-Ala-His dipeptidase -
DT426_RS11810 2299205..2300014 + 810 WP_000678376.1 C39 family peptidase -
DT426_RS11815 2300040..2300645 + 606 WP_000527413.1 hypothetical protein -
DT426_RS11820 2300786..2301037 - 252 WP_000821942.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T108291 WP_000624981.1 NZ_CP030982:2295576-2296313 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T108291 NZ_CP030982:2295576-2296313 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT108291 WP_000237817.1 NZ_CP030982:2296426-2296554 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp

>AT108291 NZ_CP030982:2296426-2296554 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References