Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 1849..2383 Replicon plasmid pYV
Accession NZ_CP030981
Organism Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3NX04
Locus tag YEY1_RS21215 Protein ID WP_014609469.1
Coordinates 2084..2383 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P0C2N3
Locus tag YEY1_RS21210 Protein ID WP_005176524.1
Coordinates 1849..2091 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YEY1_RS21855 1..966 + 966 WP_014609466.1 ParB/RepB/Spo0J family plasmid partition protein -
YEY1_RS21205 1391..1683 + 293 Protein_2 IS6 family transposase -
YEY1_RS21210 1849..2091 + 243 WP_005176524.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
YEY1_RS21215 2084..2383 + 300 WP_014609469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YEY1_RS21220 2523..3182 - 660 WP_010891237.1 type III secretion system effector GTPase activator YopE -
YEY1_RS21225 3375..3767 + 393 WP_010891236.1 type III secretion system chaperone SycE/YerA -
YEY1_RS21230 4002..5174 + 1173 Protein_7 IS3 family transposase -
YEY1_RS21235 5378..5803 + 426 WP_010891235.1 type III secretion system chaperone SycH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - yopE / sycE/yerA / sycH / yopH / lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscO / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB / yopD / yopM / sycT / yopT / yopK/yopQ / yopJ/yopP / yopO/ypkA / yadA 1..72411 72411
- flank IS/Tn - - 4549..5052 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11664.24 Da        Isoelectric Point: 5.1053

>T108289 WP_014609469.1 NZ_CP030981:2084-2383 [Yersinia enterocolitica subsp. palearctica]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDAQDFPEYE

Download         Length: 300 bp

>T108289 NZ_CP030981:2084-2383 [Yersinia enterocolitica subsp. palearctica]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGCTCAGGATTTTCCAGAGTATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8856.15 Da        Isoelectric Point: 6.7232

>AT108289 WP_005176524.1 NZ_CP030981:1849-2091 [Yersinia enterocolitica subsp. palearctica]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT108289 NZ_CP030981:1849-2091 [Yersinia enterocolitica subsp. palearctica]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAACGCACCTGTGAGCCATCGCTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3NX04

Antitoxin

Source ID Structure
AlphaFold DB A1JUB1

References