Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3279898..3280516 Replicon chromosome
Accession NZ_CP030980
Organism Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YEY1_RS15370 Protein ID WP_002208622.1
Coordinates 3280313..3280516 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag YEY1_RS15365 Protein ID WP_005163463.1
Coordinates 3279898..3280266 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YEY1_RS15330 3275552..3275812 + 261 WP_005163438.1 type B 50S ribosomal protein L31 -
YEY1_RS15335 3275828..3275971 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YEY1_RS15340 3276099..3276977 - 879 WP_005163442.1 metal ABC transporter substrate-binding protein -
YEY1_RS15345 3277040..3277897 - 858 WP_005163445.1 metal ABC transporter permease -
YEY1_RS15350 3277911..3278621 - 711 WP_014609124.1 ABC transporter ATP-binding protein -
YEY1_RS15360 3279387..3279740 + 354 WP_005163460.1 hypothetical protein -
YEY1_RS15365 3279898..3280266 + 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
YEY1_RS15370 3280313..3280516 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YEY1_RS15380 3281353..3281658 + 306 WP_005163466.1 MGMT family protein -
YEY1_RS15385 3281710..3282240 - 531 WP_005163468.1 YbaY family lipoprotein -
YEY1_RS15390 3282501..3283364 + 864 WP_005163474.1 acyl-CoA thioesterase II -
YEY1_RS15395 3283478..3284767 - 1290 WP_005167660.1 ammonium transporter AmtB -
YEY1_RS15400 3284807..3285145 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T108286 WP_002208622.1 NZ_CP030980:3280313-3280516 [Yersinia enterocolitica subsp. palearctica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T108286 NZ_CP030980:3280313-3280516 [Yersinia enterocolitica subsp. palearctica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT108286 WP_005163463.1 NZ_CP030980:3279898-3280266 [Yersinia enterocolitica subsp. palearctica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT108286 NZ_CP030980:3279898-3280266 [Yersinia enterocolitica subsp. palearctica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 2K5S


Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References