Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3279898..3280516 | Replicon | chromosome |
Accession | NZ_CP030980 | ||
Organism | Yersinia enterocolitica subsp. palearctica strain Y1 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | Q66DR5 |
Locus tag | YEY1_RS15370 | Protein ID | WP_002208622.1 |
Coordinates | 3280313..3280516 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A7U7FKE5 |
Locus tag | YEY1_RS15365 | Protein ID | WP_005163463.1 |
Coordinates | 3279898..3280266 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
YEY1_RS15330 | 3275552..3275812 | + | 261 | WP_005163438.1 | type B 50S ribosomal protein L31 | - |
YEY1_RS15335 | 3275828..3275971 | + | 144 | WP_002208618.1 | type B 50S ribosomal protein L36 | - |
YEY1_RS15340 | 3276099..3276977 | - | 879 | WP_005163442.1 | metal ABC transporter substrate-binding protein | - |
YEY1_RS15345 | 3277040..3277897 | - | 858 | WP_005163445.1 | metal ABC transporter permease | - |
YEY1_RS15350 | 3277911..3278621 | - | 711 | WP_014609124.1 | ABC transporter ATP-binding protein | - |
YEY1_RS15360 | 3279387..3279740 | + | 354 | WP_005163460.1 | hypothetical protein | - |
YEY1_RS15365 | 3279898..3280266 | + | 369 | WP_005163463.1 | Hha toxicity modulator TomB | Antitoxin |
YEY1_RS15370 | 3280313..3280516 | + | 204 | WP_002208622.1 | expression modulating protein YmoA | Toxin |
YEY1_RS15380 | 3281353..3281658 | + | 306 | WP_005163466.1 | MGMT family protein | - |
YEY1_RS15385 | 3281710..3282240 | - | 531 | WP_005163468.1 | YbaY family lipoprotein | - |
YEY1_RS15390 | 3282501..3283364 | + | 864 | WP_005163474.1 | acyl-CoA thioesterase II | - |
YEY1_RS15395 | 3283478..3284767 | - | 1290 | WP_005167660.1 | ammonium transporter AmtB | - |
YEY1_RS15400 | 3284807..3285145 | - | 339 | WP_002208627.1 | P-II family nitrogen regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8063.31 Da Isoelectric Point: 6.4573
>T108286 WP_002208622.1 NZ_CP030980:3280313-3280516 [Yersinia enterocolitica subsp. palearctica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK
Download Length: 204 bp
>T108286 NZ_CP030980:3280313-3280516 [Yersinia enterocolitica subsp. palearctica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 14192.90 Da Isoelectric Point: 4.3377
>AT108286 WP_005163463.1 NZ_CP030980:3279898-3280266 [Yersinia enterocolitica subsp. palearctica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT
Download Length: 369 bp
>AT108286 NZ_CP030980:3279898-3280266 [Yersinia enterocolitica subsp. palearctica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2K5S |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 2MN2 | |
AlphaFold DB | A0A7U7FKE5 |