Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 894072..894744 Replicon chromosome
Accession NZ_CP030980
Organism Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag YEY1_RS04040 Protein ID WP_005166047.1
Coordinates 894319..894744 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag YEY1_RS04035 Protein ID WP_004390965.1
Coordinates 894072..894338 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YEY1_RS04015 889687..890289 - 603 WP_005164134.1 HD domain-containing protein -
YEY1_RS04020 890520..891203 + 684 WP_005180855.1 hemolysin III family protein -
YEY1_RS04025 891615..892617 - 1003 Protein_757 IS110 family transposase -
YEY1_RS04030 892813..893805 - 993 WP_005166051.1 tRNA-modifying protein YgfZ -
YEY1_RS04035 894072..894338 + 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
YEY1_RS04040 894319..894744 + 426 WP_005166047.1 protein YgfX Toxin
YEY1_RS04045 894744..895442 + 699 WP_005166045.1 two-component system response regulator CreB -
YEY1_RS04050 895453..896875 + 1423 Protein_762 two-component system sensor histidine kinase CreC -
YEY1_RS04055 896967..898388 + 1422 WP_005166043.1 cell envelope integrity protein CreD -
YEY1_RS04060 898447..898965 - 519 WP_005166042.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T108275 WP_005166047.1 NZ_CP030980:894319-894744 [Yersinia enterocolitica subsp. palearctica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T108275 NZ_CP030980:894319-894744 [Yersinia enterocolitica subsp. palearctica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT108275 WP_004390965.1 NZ_CP030980:894072-894338 [Yersinia enterocolitica subsp. palearctica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT108275 NZ_CP030980:894072-894338 [Yersinia enterocolitica subsp. palearctica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References