Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 584814..585341 Replicon chromosome
Accession NZ_CP030980
Organism Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)


Gene name relE Uniprot ID A0A7T9XW08
Locus tag YEY1_RS02760 Protein ID WP_005166250.1
Coordinates 585066..585341 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7T9XW39
Locus tag YEY1_RS02755 Protein ID WP_005166251.1
Coordinates 584814..585062 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YEY1_RS02730 581413..582507 + 1095 WP_005166255.1 LPS export ABC transporter permease LptF -
YEY1_RS02735 582507..583577 + 1071 WP_005166254.1 LPS export ABC transporter permease LptG -
YEY1_RS02745 583874..584383 - 510 Protein_512 helix-turn-helix domain containing protein -
YEY1_RS02750 584444..584737 + 294 Protein_513 DUF4942 domain-containing protein -
YEY1_RS02755 584814..585062 + 249 WP_005166251.1 ribbon-helix-helix domain-containing protein Antitoxin
YEY1_RS02760 585066..585341 + 276 WP_005166250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YEY1_RS02765 585460..586248 + 789 WP_005166249.1 helix-turn-helix domain-containing protein -
YEY1_RS02770 586476..586607 + 132 Protein_517 IS3 family transposase -
YEY1_RS02775 586661..587386 - 726 WP_005180647.1 IS21-like element ISYen2A/ISYen2B family helper ATPase IstB -
YEY1_RS02780 587373..588881 - 1509 WP_005180650.1 IS21-like element ISYen2A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10974.31 Da        Isoelectric Point: 4.5486

>T108274 WP_005166250.1 NZ_CP030980:585066-585341 [Yersinia enterocolitica subsp. palearctica]
MEIYWTLKAQDDLERIYCFALQYSRQHGDDVLDRLITGCAGLTAYPAIGVQQTRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T108274 NZ_CP030980:585066-585341 [Yersinia enterocolitica subsp. palearctica]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACTGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGGCGATGACGTTTTGGATCGCCTGATTACAGGCTGTGCTGGTCTTACAGCGTATCCGGCAATTGGCGTACAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTATGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9034.30 Da        Isoelectric Point: 6.4624

>AT108274 WP_005166251.1 NZ_CP030980:584814-585062 [Yersinia enterocolitica subsp. palearctica]
MGSLTKQTISAQIPVELATAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
QS

Download         Length: 249 bp

>AT108274 NZ_CP030980:584814-585062 [Yersinia enterocolitica subsp. palearctica]
ATGGGTTCGCTTACTAAACAAACTATCAGCGCACAGATACCTGTTGAGTTGGCTACTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGTTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTCGCGGATGTGGATGCTGGTCGCGTGGTGAGCCACTCGGACATGGTAGATTTTGCTAATCGCTTAAAG
CAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XW08

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9XW39

References