Detailed information of TA system TA108271

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 104783..105367
• Replicon: chromosome
• Accession: NZ_CP030980
• Organism: Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7U7ISC5
• Locus tag: YEY1_RS00430
• Protein ID: WP_005165296.1
• Coordinates: 104783..105151 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: YEY1_RS00435
• Protein ID: WP_129019424.1
• Coordinates: 105215..105367 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YEY1_RS00410	99990..100910	+	921	WP_005165286.1	ROK family protein	-
YEY1_RS00415	100995..101957	+	963	WP_005165289.1	LacI family transcriptional regulator	-
YEY1_RS00420	101991..102464	-	474	WP_005165291.1	GNAT family N-acetyltransferase	-
YEY1_RS00425	103700..104554	-	855	WP_005165294.1	DUF4942 domain-containing protein	-
YEY1_RS00430	104783..105151	-	369	WP_005165296.1	TA system toxin CbtA family protein	Toxin
YEY1_RS00435	105215..105367	-	153	WP_129019424.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
YEY1_RS00440	105436..106638	+	1203	WP_005178352.1	IS256 family transposase	-
YEY1_RS00445	106813..108276	+	1464	WP_005166182.1	alpha/beta hydrolase	-
YEY1_RS00450	108509..109915	-	1407	WP_005166180.1	filamentous hemagglutinin N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	105436..106638	1202

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (1-45)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13609.55 Da
• Isoelectric Point: 6.4731

>T108271 WP_005165296.1 NZ_CP030980:c105151-104783 [Yersinia enterocolitica subsp. palearctica]
MQTLPVTSKRAAYACLSPVIVWQSMLTYLLEQHYGLVLSDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLARTDHRGF
SCQEQSPFITSIDILRARRATGLMTRMGYQTITSVIRGGKQA

Nucleotide

• Length: 369 bp

>T108271 NZ_CP030980:c105151-104783 [Yersinia enterocolitica subsp. palearctica]
ATGCAGACCTTACCTGTCACCTCGAAACGGGCGGCCTACGCTTGCCTATCACCCGTTATTGTCTGGCAATCCATGCTCAC
GTATCTGCTAGAGCAGCATTACGGCCTGGTGCTTAGCGACACCGAGTTCAGTGATGACGCCGTTATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGCTGAATTTCACGGTGGAGAAGTTTGACTTGGCTCGCACCGATCACCGAGGTTTC
TCCTGCCAGGAACAATCTCCCTTTATCACGTCTATCGATATTCTCCGCGCTCGTCGAGCCACCGGTCTGATGACCCGTAT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGGAAAGCAGGCATGA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5593.44 Da
• Isoelectric Point: 4.5803

>AT108271 WP_129019424.1 NZ_CP030980:c105367-105215 [Yersinia enterocolitica subsp. palearctica]
MELMLLSGELNPRYQHCVTLYRNGLICEADSLGSQGYVYLAIYPTPQSIA

Nucleotide

• Length: 153 bp

>AT108271 NZ_CP030980:c105367-105215 [Yersinia enterocolitica subsp. palearctica]
CTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGCGTCACGTTGTATCGCAATGGCTTGATCTG
CGAAGCCGATAGCCTGGGATCACAGGGTTATGTGTATCTCGCCATTTATCCTACTCCCCAATCAATTGCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7ISC5