Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 43598..44241 Replicon chromosome
Accession NZ_CP030980
Organism Yersinia enterocolitica subsp. palearctica strain Y1

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag YEY1_RS00175 Protein ID WP_005161957.1
Coordinates 43822..44241 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag YEY1_RS00170 Protein ID WP_005161959.1
Coordinates 43598..43825 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YEY1_RS00145 38711..39874 + 1164 WP_005161974.1 mannitol-1-phosphate 5-dehydrogenase -
YEY1_RS00150 40106..40660 + 555 WP_005161972.1 MltR family transcriptional regulator -
YEY1_RS00155 40657..41268 - 612 WP_016266331.1 LysE family translocator -
YEY1_RS00160 41536..43017 + 1482 WP_005161967.1 PLP-dependent aminotransferase family protein -
YEY1_RS00165 43110..43466 + 357 WP_005161962.1 YibL family ribosome-associated protein -
YEY1_RS00170 43598..43825 + 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
YEY1_RS00175 43822..44241 + 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
YEY1_RS00180 44395..45066 - 672 WP_005161954.1 6-N-hydroxylaminopurine resistance protein -
YEY1_RS00185 45145..47094 - 1950 WP_005161951.1 methyl-accepting chemotaxis protein -
YEY1_RS00190 47418..48041 - 624 WP_133964377.1 superoxide dismutase [Mn] -
YEY1_RS00195 48168..49022 - 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T108270 WP_005161957.1 NZ_CP030980:43822-44241 [Yersinia enterocolitica subsp. palearctica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T108270 NZ_CP030980:43822-44241 [Yersinia enterocolitica subsp. palearctica]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT108270 WP_005161959.1 NZ_CP030980:43598-43825 [Yersinia enterocolitica subsp. palearctica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT108270 NZ_CP030980:43598-43825 [Yersinia enterocolitica subsp. palearctica]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References