Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4439346..4439941 Replicon chromosome
Accession NZ_CP030939
Organism Escherichia coli strain AMSHJX01

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag DTO54_RS23340 Protein ID WP_000239576.1
Coordinates 4439346..4439696 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag DTO54_RS23345 Protein ID WP_001223208.1
Coordinates 4439690..4439941 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTO54_RS23320 4434792..4435814 - 1023 WP_001296689.1 ABC transporter permease -
DTO54_RS23325 4435828..4437330 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
DTO54_RS23330 4437470..4438426 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
DTO54_RS23335 4438736..4439266 + 531 WP_000055075.1 inorganic diphosphatase -
DTO54_RS23340 4439346..4439696 - 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
DTO54_RS23345 4439690..4439941 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
DTO54_RS23350 4440153..4440494 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
DTO54_RS23355 4440497..4444276 - 3780 WP_053902332.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T108265 WP_000239576.1 NZ_CP030939:c4439696-4439346 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T108265 NZ_CP030939:c4439696-4439346 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTAGGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT108265 WP_001223208.1 NZ_CP030939:c4439941-4439690 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT108265 NZ_CP030939:c4439941-4439690 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References