Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 332812..333509 Replicon chromosome
Accession NZ_CP030929
Organism Aurantimicrobium sp. MWH-Uga1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AURUGA1_RS01720 Protein ID WP_162784029.1
Coordinates 333108..333509 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AURUGA1_RS01715 Protein ID WP_205214658.1
Coordinates 332812..333108 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AURUGA1_RS01690 327818..329608 + 1791 WP_114128595.1 ABC-F family ATP-binding cassette domain-containing protein -
AURUGA1_RS01695 329609..330121 - 513 WP_114128596.1 MarR family transcriptional regulator -
AURUGA1_RS01705 330285..331706 + 1422 WP_114128597.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
AURUGA1_RS01710 331747..332724 + 978 WP_114128598.1 ribose-phosphate diphosphokinase -
AURUGA1_RS01715 332812..333108 + 297 WP_205214658.1 antitoxin Antitoxin
AURUGA1_RS01720 333108..333509 + 402 WP_162784029.1 type II toxin-antitoxin system VapC family toxin Toxin
AURUGA1_RS01725 333502..334344 - 843 WP_114128600.1 hypothetical protein -
AURUGA1_RS01730 334349..335293 - 945 WP_114128601.1 carbohydrate kinase -
AURUGA1_RS01735 335338..336786 - 1449 WP_114128602.1 NADP-dependent phosphogluconate dehydrogenase -
AURUGA1_RS01740 337076..337789 + 714 WP_114128603.1 50S ribosomal protein L25/general stress protein Ctc -
AURUGA1_RS01745 337798..338379 + 582 WP_114128604.1 aminoacyl-tRNA hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14655.94 Da        Isoelectric Point: 6.4662

>T108223 WP_162784029.1 NZ_CP030929:333108-333509 [Aurantimicrobium sp. MWH-Uga1]
VGYLFDTNILIHLDRHGDMKLAERIQDVLPSSGISAIAVMEMYYGVARSTRVETNLVKTQSLLSIIPIFEFTAADAYETG
MLRAELARAGTPVGPFDVCIAGQARARKLTLVTANSREFERVPGLKVENWLVS

Download         Length: 402 bp

>T108223 NZ_CP030929:333108-333509 [Aurantimicrobium sp. MWH-Uga1]
GTGGGCTACCTCTTTGACACCAACATTCTCATCCACCTTGACCGTCACGGTGATATGAAACTTGCAGAACGAATTCAAGA
TGTTCTTCCAAGTTCGGGAATCTCCGCGATTGCTGTGATGGAAATGTATTACGGTGTTGCTCGATCAACTCGAGTCGAAA
CTAATCTCGTTAAAACACAATCATTGCTGAGCATCATTCCCATCTTCGAATTCACCGCAGCAGATGCCTACGAAACAGGC
ATGCTCAGGGCAGAGTTAGCGCGTGCAGGAACTCCTGTTGGTCCTTTTGACGTGTGCATTGCGGGTCAAGCACGCGCCCG
TAAGCTCACACTTGTGACGGCGAATTCTCGAGAATTCGAACGTGTTCCCGGACTAAAGGTTGAAAACTGGCTCGTTAGTT
AG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11313.94 Da        Isoelectric Point: 4.4550

>AT108223 WP_205214658.1 NZ_CP030929:332812-333108 [Aurantimicrobium sp. MWH-Uga1]
MTVIQKIVYTLDIYKEKFMTSSKIFYNNTTQAVRLPKDVAFAQDVTEVEIFVQGETRVIAPKGRSLVAWMQTGPHFTEDF
MVDRDQPLMPEDDEGFFA

Download         Length: 297 bp

>AT108223 NZ_CP030929:332812-333108 [Aurantimicrobium sp. MWH-Uga1]
ATGACTGTGATTCAGAAGATTGTATATACTTTAGATATATACAAGGAGAAGTTCATGACTTCAAGCAAAATCTTCTATAA
CAACACCACTCAAGCAGTGAGGCTTCCAAAAGATGTTGCGTTTGCTCAAGACGTAACTGAGGTAGAGATATTTGTTCAAG
GTGAAACTCGCGTGATAGCGCCAAAGGGGCGGAGTTTGGTTGCCTGGATGCAAACAGGGCCCCACTTTACAGAAGACTTT
ATGGTCGATAGAGATCAACCACTGATGCCCGAGGATGACGAAGGATTTTTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References