Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2169800..2170457 Replicon chromosome
Accession NZ_CP030923
Organism Klebsiella pneumoniae subsp. pneumoniae strain KC-Pl-HB1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DTN91_RS10935 Protein ID WP_002916310.1
Coordinates 2170047..2170457 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DTN91_RS10930 Protein ID WP_002916312.1
Coordinates 2169800..2170066 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTN91_RS10905 2165008..2166441 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
DTN91_RS10910 2166560..2167288 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DTN91_RS10915 2167338..2167649 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DTN91_RS10920 2167813..2168472 + 660 WP_002916317.1 hemolysin III family protein -
DTN91_RS10925 2168571..2169554 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
DTN91_RS10930 2169800..2170066 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DTN91_RS10935 2170047..2170457 + 411 WP_002916310.1 protein YgfX Toxin
DTN91_RS10940 2170464..2170985 - 522 WP_002916308.1 flavodoxin FldB -
DTN91_RS10945 2171086..2171982 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DTN91_RS10950 2172005..2172718 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DTN91_RS10955 2172724..2174457 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T108208 WP_002916310.1 NZ_CP030923:2170047-2170457 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T108208 NZ_CP030923:2170047-2170457 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT108208 WP_002916312.1 NZ_CP030923:2169800-2170066 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT108208 NZ_CP030923:2169800-2170066 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References