Detailed information of TA system TA108164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 154071..154576
• Replicon: chromosome
• Accession: NZ_CP030913
• Organism: Pseudomonas aeruginosa strain Y89

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: Y89_RS00690
• Protein ID: WP_003083773.1
• Coordinates: 154071..154352 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: Y89_RS00695
• Protein ID: WP_003083775.1
• Coordinates: 154349..154576 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y89_RS00665	149322..150671	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
Y89_RS00670	150720..151406	+	687	WP_003083762.1	FadR family transcriptional regulator	-
Y89_RS00675	151507..152241	+	735	WP_023081667.1	GntR family transcriptional regulator	-
Y89_RS00680	152445..152831	+	387	WP_014602345.1	aegerolysin family protein	-
Y89_RS00685	152863..153771	-	909	WP_003083769.1	LysR family transcriptional regulator	-
Y89_RS00690	154071..154352	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
Y89_RS00695	154349..154576	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
Y89_RS00700	154752..155372	-	621	WP_003101226.1	hypothetical protein	-
Y89_RS00705	155473..155973	+	501	WP_003101228.1	LEA type 2 family protein	-
Y89_RS00710	156046..156387	+	342	WP_023081666.1	alkylphosphonate utilization protein	-
Y89_RS00715	156487..157071	-	585	WP_073674849.1	DUF4276 family protein	-
Y89_RS00720	157068..158276	-	1209	WP_023081665.1	AAA family ATPase	-
Y89_RS00725	158668..158781	+	114	Protein_144	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	158668..158784	116

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T108164 WP_003083773.1 NZ_CP030913:c154352-154071 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T108164 NZ_CP030913:c154352-154071 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATTGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT108164 WP_003083775.1 NZ_CP030913:c154576-154349 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT108164 NZ_CP030913:c154576-154349 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9