Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147480..147985 Replicon chromosome
Accession NZ_CP030910
Organism Pseudomonas aeruginosa strain Y31

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag Y31_RS00680 Protein ID WP_003121619.1
Coordinates 147480..147761 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag Y31_RS00685 Protein ID WP_003112628.1
Coordinates 147758..147985 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y31_RS00655 142731..144080 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
Y31_RS00660 144129..144815 + 687 WP_003083762.1 FadR family transcriptional regulator -
Y31_RS00665 144916..145650 + 735 WP_003117208.1 GntR family transcriptional regulator -
Y31_RS00670 145854..146240 + 387 WP_014602345.1 aegerolysin family protein -
Y31_RS00675 146272..147180 - 909 WP_003083769.1 LysR family transcriptional regulator -
Y31_RS00680 147480..147761 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
Y31_RS00685 147758..147985 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
Y31_RS00690 148161..148781 - 621 WP_003101226.1 hypothetical protein -
Y31_RS00695 148882..149382 + 501 WP_003101228.1 LEA type 2 family protein -
Y31_RS00700 149455..149796 + 342 WP_003101229.1 alkylphosphonate utilization protein -
Y31_RS00705 149878..151305 - 1428 WP_003083784.1 GABA permease -
Y31_RS00710 151474..152967 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T108139 WP_003121619.1 NZ_CP030910:c147761-147480 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T108139 NZ_CP030910:c147761-147480 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT108139 WP_003112628.1 NZ_CP030910:c147985-147758 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT108139 NZ_CP030910:c147985-147758 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References