Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1746028..1747160 Replicon chromosome
Accession NZ_CP030880
Organism Acinetobacter haemolyticus strain HW-2A

Toxin (Protein)


Gene name - Uniprot ID A0A2K8PX24
Locus tag DS737_RS08040 Protein ID WP_017396077.1
Coordinates 1746028..1746792 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag DS737_RS08045 Protein ID WP_004639219.1
Coordinates 1746789..1747160 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DS737_RS08015 1741936..1742793 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
DS737_RS08020 1742885..1744174 + 1290 WP_004639224.1 phosphopyruvate hydratase -
DS737_RS08025 1744304..1744669 + 366 WP_004639223.1 cell division protein FtsB -
DS737_RS08030 1744659..1745366 + 708 WP_113997251.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
DS737_RS08035 1745493..1745969 + 477 WP_113997252.1 hypothetical protein -
DS737_RS08040 1746028..1746792 - 765 WP_017396077.1 RES family NAD+ phosphorylase Toxin
DS737_RS08045 1746789..1747160 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
DS737_RS08050 1747376..1747789 + 414 WP_005080585.1 YeeE/YedE family protein -
DS737_RS08055 1747791..1748204 + 414 WP_005090445.1 YeeE/YedE family protein -
DS737_RS08060 1748219..1749091 + 873 WP_017396076.1 MBL fold metallo-hydrolase -
DS737_RS08065 1749260..1749958 + 699 WP_005080590.1 phosphoglycerate mutase family protein -
DS737_RS08070 1750100..1750360 + 261 WP_005080592.1 hypothetical protein -
DS737_RS08075 1750487..1751071 + 585 WP_113997253.1 uracil-DNA glycosylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29082.00 Da        Isoelectric Point: 5.8003

>T108138 WP_017396077.1 NZ_CP030880:c1746792-1746028 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWHSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGIEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T108138 NZ_CP030880:c1746792-1746028 [Acinetobacter haemolyticus]
ATGACCGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGATCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGCACTCAATGGATGGTGCGCCAAAGAAAAAAACGATACGCACTGAGCATA
CTCTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGCACAGCAATGCGGAATGAAGGAATTGAGATCTTTGAATATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAAAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT108138 WP_004639219.1 NZ_CP030880:c1747160-1746789 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT108138 NZ_CP030880:c1747160-1746789 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTGCTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTCGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PX24

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References