Detailed information of TA system TA108136

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 421486..422125
• Replicon: chromosome
• Accession: NZ_CP030880
• Organism: Acinetobacter haemolyticus strain HW-2A

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DS737_RS02045
• Protein ID: WP_113996648.1
• Coordinates: 421730..422125 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9FB90
• Locus tag: DS737_RS02040
• Protein ID: WP_004641025.1
• Coordinates: 421486..421743 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DS737_RS02015	416561..416926	+	366	WP_004641032.1	50S ribosomal protein L17	-
DS737_RS02020	417091..417588	+	498	WP_017395331.1	GNAT family N-acetyltransferase	-
DS737_RS02025	417966..419456	+	1491	WP_017395332.1	NAD(P)/FAD-dependent oxidoreductase	-
DS737_RS02030	419579..420076	+	498	WP_113996647.1	DUF2059 domain-containing protein	-
DS737_RS02035	420127..421299	-	1173	WP_005086825.1	acyl-CoA dehydrogenase family protein	-
DS737_RS02040	421486..421743	+	258	WP_004641025.1	succinate dehydrogenase assembly factor 2	Antitoxin
DS737_RS02045	421730..422125	+	396	WP_113996648.1	hypothetical protein	Toxin
DS737_RS02050	422336..422542	+	207	WP_026056364.1	hypothetical protein	-
DS737_RS02055	422902..423945	+	1044	WP_113996649.1	hypothetical protein	-
DS737_RS02060	424073..424654	+	582	WP_004641018.1	rhombosortase	-
DS737_RS02065	424832..427042	+	2211	WP_004641016.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	270175..432830	162655

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 16053.36 Da
• Isoelectric Point: 9.1821

>T108136 WP_113996648.1 NZ_CP030880:421730-422125 [Acinetobacter haemolyticus]
MSTADRVFVLKRSRFAFAFQLFIFIVLISLLYYLLPWFLWLVSFPLMLIAWVLLLKQPQLKHFEYLDDQLCSLCFSDEMQ
GIEQRKIRKMIDHQCYIVIYFYDSQCRPCVIWWDQLSILQWKKLKKWVKLA

Nucleotide

• Length: 396 bp

>T108136 NZ_CP030880:421730-422125 [Acinetobacter haemolyticus]
ATGTCCACGGCTGATCGTGTTTTTGTGTTGAAACGCAGTCGTTTTGCATTTGCGTTTCAACTTTTTATTTTTATCGTATT
GATCAGCTTATTGTATTACTTACTTCCTTGGTTTTTATGGCTTGTTAGCTTTCCTTTGATGCTAATTGCTTGGGTATTAT
TACTCAAACAACCTCAGCTTAAGCACTTTGAATATTTAGATGATCAGCTTTGCTCCTTGTGTTTTAGTGATGAGATGCAG
GGGATCGAGCAAAGGAAAATTCGAAAAATGATCGATCATCAATGTTATATCGTCATCTATTTTTATGACTCTCAATGTCG
ACCTTGTGTGATTTGGTGGGATCAATTGTCGATTTTACAGTGGAAAAAGCTCAAAAAATGGGTCAAACTTGCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9982.42 Da
• Isoelectric Point: 4.4558

>AT108136 WP_004641025.1 NZ_CP030880:421486-421743 [Acinetobacter haemolyticus]
MSEELTLEERKVIYRARRGLKEIDVYFDPYVKNCYLTADAAEKALFAELVDQEDPDLLDWFMEVGEPPRPELKAFISKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT108136 NZ_CP030880:421486-421743 [Acinetobacter haemolyticus]
ATGTCTGAAGAATTGACACTAGAAGAACGTAAAGTGATTTATCGTGCGCGTCGTGGTTTGAAAGAAATCGATGTGTATTT
TGATCCTTATGTCAAAAATTGTTATCTCACAGCAGATGCGGCTGAGAAAGCATTGTTTGCAGAGTTGGTAGATCAAGAAG
ATCCTGATTTACTGGATTGGTTCATGGAGGTCGGTGAACCTCCTCGTCCAGAGTTAAAAGCGTTTATTTCAAAATTAAAA
CAGTATGTCCACGGCTGA

Structures

Antitoxin

• AlphaFold DB: N9FB90