108134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4123950..4124569 Replicon chromosome
Accession NZ_CP030874
Organism Raoultella sp. X13

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag DSD31_RS19585 Protein ID WP_004858783.1
Coordinates 4124351..4124569 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag DSD31_RS19580 Protein ID WP_004858785.1
Coordinates 4123950..4124324 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSD31_RS19570 4119060..4120253 + 1194 WP_004858789.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DSD31_RS19575 4120276..4123422 + 3147 WP_004858787.1 multidrug efflux RND transporter permease subunit -
DSD31_RS19580 4123950..4124324 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
DSD31_RS19585 4124351..4124569 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
DSD31_RS19590 4124721..4125287 + 567 WP_004858781.1 maltose O-acetyltransferase -
DSD31_RS19595 4125387..4125857 + 471 WP_004858780.1 YlaC family protein -
DSD31_RS19600 4125832..4127283 - 1452 WP_032716766.1 PLP-dependent aminotransferase family protein -
DSD31_RS19605 4127387..4128097 + 711 WP_015585015.1 GNAT family N-acetyltransferase -
DSD31_RS19610 4128094..4128234 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
DSD31_RS19615 4128237..4128497 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T108134 WP_004858783.1 NZ_CP030874:4124351-4124569 [Raoultella sp. X13]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T108134 NZ_CP030874:4124351-4124569 [Raoultella sp. X13]
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGTCGCTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTTCAGATAACGAACTGGCTGTATTTTACTCAGCGGCCGACCACCGTCTTGCTGAAT
TGACCATGAATAAGCTCTACGACAAAATCCCGACATCGGTGTGGAAGTTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT108134 WP_004858785.1 NZ_CP030874:4123950-4124324 [Raoultella sp. X13]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT108134 NZ_CP030874:4123950-4124324 [Raoultella sp. X13]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCGCAGCTTCGATTTCTTTGCGAAACCCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGTAACCACGGGTGGGTGAATGATCCAACGTCGGCTATTAATCTTCAACTTAATGAATTGATCGAAC
ACATAGCCACGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAACTGATCGCTCAGCTGGACGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGCATTAACACGGCCGATCTACAGAAATGGCGCAAATCGGGAAATCGGTT
ATTCCGATGTTTTGTCAACGCCAGTCGGGAAAATCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References