Detailed information of TA system TA108133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2709235..2710838
• Replicon: chromosome
• Accession: NZ_CP030874
• Organism: Raoultella sp. X13

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: DSD31_RS12955
• Protein ID: WP_113991088.1
• Coordinates: 2709235..2710566 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A808YAX5
• Locus tag: DSD31_RS12960
• Protein ID: WP_032717448.1
• Coordinates: 2710566..2710838 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSD31_RS12940	2705109..2706023	-	915	WP_015584333.1	branched-chain amino acid ABC transporter permease	-
DSD31_RS12945	2706123..2707181	-	1059	WP_162180097.1	branched-chain amino acid ABC transporter substrate-binding protein	-
DSD31_RS12950	2707896..2709302	+	1407	WP_113991394.1	glycoside hydrolase family 10 protein	-
DSD31_RS12955	2709235..2710566	-	1332	WP_113991088.1	type II toxin-antitoxin system HipA family toxin	Toxin
DSD31_RS12960	2710566..2710838	-	273	WP_032717448.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
DSD31_RS12965	2711042..2711596	-	555	WP_004861926.1	RNA polymerase sigma factor	-
DSD31_RS12970	2711602..2712027	-	426	WP_032724724.1	hypothetical protein	-
DSD31_RS12975	2712160..2713113	-	954	WP_004861921.1	hypothetical protein	-
DSD31_RS12980	2713327..2713962	-	636	Protein_2484	class I SAM-dependent methyltransferase	-
DSD31_RS12985	2714011..2715209	-	1199	Protein_2485	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 49373.68 Da
• Isoelectric Point: 6.5070

>T108133 WP_113991088.1 NZ_CP030874:c2710566-2709235 [Raoultella sp. X13]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWELLDNHDLDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGDQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Nucleotide

• Length: 1332 bp

>T108133 NZ_CP030874:c2710566-2709235 [Raoultella sp. X13]
ATGGCGACTCTCGTGACATGGATGAACAATGAGCGGGTCGGCGAGCTAATCAAGCAGGCGAACGGCGCACATCTCTTTCG
CTATGAAGAGGCGTGGATGCGCAATCCTCGCGCCAGACCGCTCTCACTGTCGCTTCCGCTGCAGTACGGTAACATCACCG
ACGAGGCGGTATTTAACTACTTTGACAATCTGCTGCCGGACAGTCCGCGGGTACGGGACCGCATTGTTAAGCGCTATCAG
GCGCGTTCAAAGCAGCCGTTTGATCTGCTGGCCGAGATCGGACGGGACAGCGTCGGGGCGGTAACGTTACTCCCGCCAGG
AGAAAATGCGCCCCGCGGGGCGTTGAGCTGGGAGCTGCTGGATAACCACGATCTGGATGCGTTACTGACGGCCTACCAGT
CGGATATACCGCTCGGAATGGTCAACGAACACGATGATTTCAGGATCTCGGTGGCCGGGGCCCAGGAGAAAACCGCGCTG
CTGAAAATCGGCGATCAGTGGTGTATCCCGACGGGTACCACGCCGACTACCCACATCATTAAACTGCCCATCGGCGAGAT
CAAACAGCCGGATGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATTTGTGTCTGGCGCTGGCCCGGGCGCTGG
GTTTTGCCGTTCCGCCCGCCAGCATTATCCAGACAGCCAGTATCAGGGCGCTGGCGGTGGAGCGTTTCGACCGTCGCTGG
GCGCAGGAGAAAACGGTGCTGCTGCGTTTGCCGCAGGAAGATCTGTGTCAGGCCTTCGGCATTCCGTCATCGATTAAGTA
TGAGTCCGACGGCGGGCCGGGCATTCGGGCAATTATGGCTTTTCTGGTTGGCTCCAGCGAGGCACTCGAGGATCGCTATA
ACTTTATGAAGTTTATGGTGTTCCAGTGGCTGATTGGCGCAACCGATGGCCACGCCAAAAACTTCTCGATTTTCCTCCAG
CCGGGCGGCAGCTACCGCTTAACCCCGTTCTACGACATTATCTCCGCGTTTCCGCTGCTTGGCGGAAAGGGACTGCACCT
GAGCGATCTCAAGCTGTCGATGAGTCTGAAGGCCAGTAAAGGGCGTAAAACGGAGATCCAGACGCTCTATCCGCGTCACT
TTCTCGCCACGGCTAAAGAGGTAGGGTTTGCCCAACAGCAGATGCTGGAGATTCTGCGCTATTTTGTCGATAACGTTCCC
CGCGCGGTTGAGGCGGTAAAGGGGACTTTACCGCCTGACTTTTCACAACCGGTATATGAGGCGATCACCGATCGCTTGCT
GTGGGTCCATTCACGCTTGCAGAACGCAATGGCGGCGTCTCCGTCGGGCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10365.71 Da
• Isoelectric Point: 5.7971

>AT108133 WP_032717448.1 NZ_CP030874:c2710838-2710566 [Raoultella sp. X13]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Nucleotide

• Length: 273 bp

>AT108133 NZ_CP030874:c2710838-2710566 [Raoultella sp. X13]
ATGAGCCCTTCACCAACGATATACAGCCCGGTTCAGCTGGCAAACTATCTCAAGCTGGTGCGCCAGAAAAACCAGTGGAC
GCAGAGCGAGCTGGCTCAGCGTATGGGGATTAAACAGGCCACCGTCTCTAACTTTGAAAATCATCCCGAGAAAACGACGT
TAACCACGGTGTTTAAAATTTTACAGTCACTGGAACTGTCGATGGCGATTTGCGAAAAAAATGCGCCGGATACCGACGAT
AACCGTGATAACCCGCGGGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A808YAX5