Detailed information of TA system TA108131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2381977..2382890
• Replicon: chromosome
• Accession: NZ_CP030874
• Organism: Raoultella sp. X13

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y4A8
• Locus tag: DSD31_RS11310
• Protein ID: WP_015584188.1
• Coordinates: 2381977..2382450 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y7A4
• Locus tag: DSD31_RS11315
• Protein ID: WP_004862777.1
• Coordinates: 2382447..2382890 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSD31_RS11285	2378016..2378624	-	609	WP_032724246.1	glutathione S-transferase family protein	-
DSD31_RS11290	2378866..2379771	+	906	WP_032716408.1	transcriptional regulator GcvA	-
DSD31_RS11295	2379799..2380704	-	906	WP_032716407.1	LysR family transcriptional regulator	-
DSD31_RS11300	2380807..2381124	+	318	WP_004862785.1	nuclear transport factor 2 family protein	-
DSD31_RS11305	2381117..2381896	+	780	WP_004862782.1	SDR family oxidoreductase	-
DSD31_RS11310	2381977..2382450	-	474	WP_015584188.1	RES domain-containing protein	Toxin
DSD31_RS11315	2382447..2382890	-	444	WP_004862777.1	DUF2384 domain-containing protein	Antitoxin
DSD31_RS11320	2383080..2383646	-	567	WP_015584190.1	DJ-1/PfpI family protein	-
DSD31_RS11325	2384044..2384826	+	783	WP_032717546.1	DUF3750 domain-containing protein	-
DSD31_RS11330	2385023..2386246	+	1224	WP_004862767.1	zinc metallochaperone GTPase ZigA	-
DSD31_RS11350	2387177..2387656	-	480	WP_113991048.1	acid resistance repetitive basic protein Asr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17524.82 Da
• Isoelectric Point: 4.8081

>T108131 WP_015584188.1 NZ_CP030874:c2382450-2381977 [Raoultella sp. X13]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T108131 NZ_CP030874:c2382450-2381977 [Raoultella sp. X13]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGGACAGTGAAGTGGAATCCCTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTTTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16190.45 Da
• Isoelectric Point: 4.9405

>AT108131 WP_004862777.1 NZ_CP030874:c2382890-2382447 [Raoultella sp. X13]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT108131 NZ_CP030874:c2382890-2382447 [Raoultella sp. X13]
ATGAAAACCTGGGTTCCTGCAGAGCAACCTGCCGATAATGCGCTGTGGCGCTATGCCGGGCTACCGGCGAATCGGGGTAT
GCAGTTGATTGAGCTGCTGAGTATGGGATTACCGGTCAGCATTCTGGATAATATTCATGAGTGGACGGAAATGTCGAAAA
CCGACATTCTGCGCATCACCGGGATTAATGAGCGCAACGTTGCCCGGCGCAAGAGCGCGGGCGGCACGTTGACGCCAGGC
GAAAGCGAACGTGTGGCGCGTTTTGTCAGGGTCCTGGATACCGCCGTCGACTATTTTGGCAGCAAGCAGGATGCCTACGA
CTGGCTGCAGTCGCCGGTCAGAGGACTGGGCAATGTCGCCCCCATCGACCTGATTGCTACCGAGAGCGGCGCGCTGGAAG
TAACAGACCTGATTGGTCGCCTGGAACACGGCGTCTTTGCATGA

Structures

Toxin

• AlphaFold DB: A0A808Y4A8

Antitoxin

• AlphaFold DB: A0A808Y7A4