Detailed information of TA system TA108122

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1223198..1223865
• Replicon: chromosome
• Accession: NZ_CP030874
• Organism: Raoultella sp. X13

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A808XXQ9
• Locus tag: DSD31_RS06005
• Protein ID: WP_063844052.1
• Coordinates: 1223198..1223527 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: DSD31_RS06010
• Protein ID: WP_113990883.1
• Coordinates: 1223548..1223865 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSD31_RS05980	1218258..1219421	-	1164	WP_004866618.1	MFS transporter	-
DSD31_RS05985	1219439..1220344	-	906	WP_196770161.1	hypothetical protein	-
DSD31_RS05990	1220752..1221939	-	1188	WP_004866608.1	ROK family transcriptional regulator	-
DSD31_RS06000	1222672..1222817	-	146	Protein_1144	transposase	-
DSD31_RS06005	1223198..1223527	-	330	WP_063844052.1	TA system toxin CbtA family protein	Toxin
DSD31_RS06010	1223548..1223865	-	318	WP_113990883.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DSD31_RS06015	1223884..1224105	-	222	WP_113990884.1	DUF987 domain-containing protein	-
DSD31_RS06020	1224114..1224596	-	483	WP_058649301.1	DNA repair protein RadC	-
DSD31_RS06025	1224605..1225063	-	459	WP_064411435.1	antirestriction protein	-
DSD31_RS06030	1225181..1225396	-	216	Protein_1150	DUF905 domain-containing protein	-
DSD31_RS06035	1225474..1225884	-	411	WP_113990885.1	hypothetical protein	-
DSD31_RS06040	1225951..1226388	-	438	WP_113990886.1	hypothetical protein	-
DSD31_RS06045	1226430..1226966	-	537	WP_113990887.1	DUF4339 domain-containing protein	-
DSD31_RS06050	1226992..1227702	-	711	WP_113990888.1	DeoR family transcriptional regulator	-
DSD31_RS06055	1227911..1228735	-	825	WP_113990889.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1223198..1249975	26777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12357.37 Da
• Isoelectric Point: 9.5732

>T108122 WP_063844052.1 NZ_CP030874:c1223527-1223198 [Raoultella sp. X13]
MKTLPATISRATKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDKTVIQEHIDAGVSLSDAVNFLVEKYELVRIDRKAF
SWQEQTPYISVVDILRARRSTGLLKANVK

Nucleotide

• Length: 330 bp

>T108122 NZ_CP030874:c1223527-1223198 [Raoultella sp. X13]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGACGAAGCCCTGTCTGTCGCCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATAAAACAGTTATTCAGGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGAGCTTGTCCGTATCGACCGGAAGGCGTTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGATTGCTAAAAGCTAA
CGTGAAATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11969.55 Da
• Isoelectric Point: 6.8412

>AT108122 WP_113990883.1 NZ_CP030874:c1223865-1223548 [Raoultella sp. X13]
MSNITWGLQRDTTPRLGARLVQEGNRLYYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTVEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 318 bp

>AT108122 NZ_CP030874:c1223865-1223548 [Raoultella sp. X13]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGCAACCGGCT
GTACTATCTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACGCTGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCACTGTTGAAATGAATCCCCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGACACTCTTGGCAGTTGCGGCTATGTATACATCGCCGTCTATCCCACTCAACGCTAA

Structures

Toxin

• AlphaFold DB: A0A808XXQ9