108117

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/VapC-MazE
Location 93119..93780 Replicon plasmid unnamed1
Accession NZ_CP030872
Organism Acetobacter sp. JWB

Toxin (Protein)


Gene name vapC Uniprot ID C7JIL1
Locus tag DS739_RS13690 Protein ID WP_006115553.1
Coordinates 93119..93427 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID C7JIL0
Locus tag DS739_RS13695 Protein ID WP_006115554.1
Coordinates 93526..93780 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DS739_RS13655 88473..88622 - 150 WP_007397858.1 DUF2474 domain-containing protein -
DS739_RS13660 88609..89628 - 1020 WP_006115550.1 cytochrome d ubiquinol oxidase subunit II -
DS739_RS13665 89631..91064 - 1434 WP_006115551.1 cytochrome ubiquinol oxidase subunit I -
DS739_RS13675 91500..92459 - 960 WP_035350857.1 IS481 family transposase -
DS739_RS13680 92517..92777 + 261 Protein_82 hypothetical protein -
DS739_RS13685 92850..93122 + 273 WP_006115552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
DS739_RS13690 93119..93427 + 309 WP_006115553.1 PIN domain-containing protein Toxin
DS739_RS13695 93526..93780 + 255 WP_006115554.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DS739_RS13700 93782..94111 + 330 WP_012813213.1 endoribonuclease MazF -
DS739_RS13705 94168..94368 + 201 WP_012813212.1 hypothetical protein -
DS739_RS13710 94398..94718 + 321 WP_012813211.1 hypothetical protein -
DS739_RS13715 94775..95179 - 405 WP_006115557.1 hypothetical protein -
DS739_RS13720 95192..96007 - 816 WP_006115558.1 hypothetical protein -
DS739_RS13725 96104..96568 - 465 WP_039891560.1 hypothetical protein -
DS739_RS13730 96571..97419 - 849 WP_039891563.1 hypothetical protein -
DS739_RS13735 97536..98324 - 789 WP_006115561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..137977 137977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-87)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 10974.72 Da        Isoelectric Point: 4.4353

>T108117 WP_006115553.1 NZ_CP030872:93119-93427 [Acetobacter sp. JWB]
VSIYLLDTNIISDLVRNPSGSCAQRIEHIDPGDLCTSIIVAAELRYGCAKKGSEKLLNRVESVLAFIPVLPLDIPADCEY
GGIRAELEAAGQTIGMLEKLFA

Download         Length: 309 bp

>T108117 NZ_CP030872:93119-93427 [Acetobacter sp. JWB]
GTGAGCATCTACCTTCTTGATACAAACATCATCAGCGATCTCGTGCGCAATCCTTCCGGCTCCTGTGCGCAACGCATTGA
GCATATTGACCCAGGTGATCTTTGCACCAGCATCATCGTGGCCGCAGAATTACGCTATGGATGCGCCAAAAAAGGCTCCG
AAAAGCTCTTGAACCGGGTCGAAAGCGTGTTGGCGTTTATCCCTGTGCTGCCACTCGATATTCCTGCCGACTGTGAATAC
GGTGGCATCCGCGCCGAACTCGAGGCGGCAGGGCAGACAATCGGCATGCTTGAGAAGCTTTTTGCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8921.28 Da        Isoelectric Point: 4.2550

>AT108117 WP_006115554.1 NZ_CP030872:93526-93780 [Acetobacter sp. JWB]
MEGAMKAVVKKWGNSASIRIPASVLAAAGLTLDQPVDVREESGRIVIEPLTVVEYDLADLLAGITPENIHPEVDFGAPVG
RELL

Download         Length: 255 bp

>AT108117 NZ_CP030872:93526-93780 [Acetobacter sp. JWB]
ATGGAGGGCGCAATGAAGGCTGTGGTAAAAAAATGGGGGAATAGTGCATCCATTCGTATCCCTGCTTCAGTATTGGCAGC
TGCTGGATTGACGTTGGATCAGCCAGTGGATGTGCGCGAGGAAAGCGGACGCATTGTCATTGAGCCGCTCACAGTCGTAG
AATACGATCTGGCGGATTTGTTGGCTGGGATCACCCCGGAGAATATTCATCCTGAAGTGGACTTCGGAGCGCCTGTTGGC
CGCGAACTCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401X8Y0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1QDC4

References