Detailed information of TA system TA108114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 20602..21152
• Replicon: plasmid unnamed1
• Accession: NZ_CP030872
• Organism: Acetobacter sp. JWB

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: DS739_RS13300
• Protein ID: WP_003618711.1
• Coordinates: 20602..20895 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: DS739_RS13305
• Protein ID: WP_003618686.1
• Coordinates: 20892..21152 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DS739_RS13280	16182..16907	-	726	Protein_9	ImuA family protein	-
DS739_RS13285	17193..17891	+	699	Protein_10	DUF1275 domain-containing protein	-
DS739_RS13290	18057..19808	+	1752	WP_114012473.1	oleate hydratase	-
DS739_RS13295	19883..20416	-	534	WP_006117365.1	hypothetical protein	-
DS739_RS13300	20602..20895	-	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DS739_RS13305	20892..21152	-	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DS739_RS13310	21366..21728	-	363	WP_012813198.1	hypothetical protein	-
DS739_RS13315	21878..22965	+	1088	WP_114012474.1	IS3 family transposase	-
DS739_RS13320	23006..23785	-	780	Protein_17	LysR family transcriptional regulator	-
DS739_RS13325	23887..24132	+	246	Protein_18	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..137977	137977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11605.35 Da
• Isoelectric Point: 7.9998

>T108114 WP_003618711.1 NZ_CP030872:c20895-20602 [Acetobacter sp. JWB]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASKRTE

Nucleotide

• Length: 294 bp

>T108114 NZ_CP030872:c20895-20602 [Acetobacter sp. JWB]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCACTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9762.23 Da
• Isoelectric Point: 10.4645

>AT108114 WP_003618686.1 NZ_CP030872:c21152-20892 [Acetobacter sp. JWB]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Nucleotide

• Length: 261 bp

>AT108114 NZ_CP030872:c21152-20892 [Acetobacter sp. JWB]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6