Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 909641..910224 Replicon chromosome
Accession NZ_CP030871
Organism Acetobacter sp. JWB

Toxin (Protein)


Gene name hicA Uniprot ID F1YT37
Locus tag DS739_RS04380 Protein ID WP_006116155.1
Coordinates 909641..909895 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F1YT36
Locus tag DS739_RS04385 Protein ID WP_006116153.1
Coordinates 909892..910224 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DS739_RS04355 906124..906288 - 165 Protein_841 IS5/IS1182 family transposase -
DS739_RS14135 906377..906607 - 231 WP_139018867.1 hypothetical protein -
DS739_RS14140 907025..907192 - 168 WP_157772570.1 hypothetical protein -
DS739_RS04365 907466..907576 - 111 Protein_844 transcriptional regulator -
DS739_RS04370 907677..907948 - 272 Protein_845 hypothetical protein -
DS739_RS04375 908202..909401 + 1200 WP_035353178.1 tyrosine-type recombinase/integrase -
DS739_RS04380 909641..909895 + 255 WP_006116155.1 type II toxin-antitoxin system HicA family toxin Toxin
DS739_RS04385 909892..910224 + 333 WP_006116153.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DS739_RS04390 910532..910846 - 315 WP_081461434.1 terminase small subunit -
DS739_RS04395 910874..912982 + 2109 WP_157772569.1 transglycosylase SLT domain-containing protein -
DS739_RS04400 912982..913245 + 264 WP_035353185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9479.92 Da        Isoelectric Point: 10.3861

>T108112 WP_006116155.1 NZ_CP030871:909641-909895 [Acetobacter sp. JWB]
MKAKHRRTLELIFKRPVSGNVPWADIEALFVSLGAEVSEREGSRIGVFLFDEVKVFHRPHPKPDTDKGAVASVRKWLEQN
GVTP

Download         Length: 255 bp

>T108112 NZ_CP030871:909641-909895 [Acetobacter sp. JWB]
ATGAAAGCCAAGCACCGCCGCACATTGGAACTGATTTTCAAGCGTCCTGTTTCGGGCAATGTGCCATGGGCAGACATTGA
AGCTTTATTTGTTTCCCTAGGGGCGGAGGTGTCTGAAAGAGAAGGCTCCCGCATAGGGGTGTTCCTGTTTGATGAGGTAA
AGGTGTTTCATAGACCTCACCCCAAACCGGATACAGACAAGGGTGCTGTAGCCTCTGTAAGAAAATGGCTTGAGCAGAAT
GGAGTGACGCCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11992.63 Da        Isoelectric Point: 4.6742

>AT108112 WP_006116153.1 NZ_CP030871:909892-910224 [Acetobacter sp. JWB]
MNNVMEIGGHRAVIQFDPEIGMFRGEFLGLNGGADFYADSVAGLQQEGETSLRVFMEMCAEKGIDPVKHYSGRFVVRLPE
DVHARAAEIAAARGISLNRLVQDVLAQVEG

Download         Length: 333 bp

>AT108112 NZ_CP030871:909892-910224 [Acetobacter sp. JWB]
ATGAACAACGTAATGGAAATTGGCGGCCATCGGGCTGTTATTCAGTTTGATCCTGAAATCGGGATGTTCCGGGGTGAGTT
TCTGGGACTGAACGGAGGGGCTGATTTCTACGCAGATAGTGTGGCAGGCCTTCAGCAGGAAGGGGAAACTTCCCTCCGTG
TCTTCATGGAGATGTGTGCTGAGAAAGGCATTGATCCCGTGAAGCATTATTCAGGCCGGTTTGTTGTGAGGCTACCAGAA
GACGTTCATGCACGGGCAGCTGAGATTGCTGCAGCACGCGGGATCAGTCTTAACCGACTGGTGCAGGATGTTTTGGCACA
GGTTGAAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401X5W6

Antitoxin

Source ID Structure
AlphaFold DB F1YT36

References