Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 6703593..6704227 Replicon chromosome
Accession NZ_CP030862
Organism Streptomyces globosus strain LZH-48

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C0216_RS29800 Protein ID WP_114058221.1
Coordinates 6703805..6704227 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C0216_RS29795 Protein ID WP_114058220.1
Coordinates 6703593..6703808 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0216_RS29765 6698658..6700847 - 2190 WP_114058217.1 DNA polymerase III subunit gamma and tau -
C0216_RS29780 6701370..6702329 + 960 WP_114058218.1 HNH endonuclease -
C0216_RS29785 6702304..6702731 - 428 Protein_5833 type II toxin-antitoxin system VapC family toxin -
C0216_RS29790 6702728..6703003 - 276 WP_114058219.1 hypothetical protein -
C0216_RS29795 6703593..6703808 + 216 WP_114058220.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C0216_RS29800 6703805..6704227 + 423 WP_114058221.1 PIN domain nuclease Toxin
C0216_RS29805 6704680..6707133 + 2454 WP_114058222.1 helicase-associated domain-containing protein -
C0216_RS33650 6707406..6707630 + 225 WP_162793317.1 hypothetical protein -
C0216_RS29820 6707882..6708616 - 735 WP_114058223.1 helix-turn-helix domain-containing protein -
C0216_RS29825 6708654..6709073 - 420 WP_114058224.1 TOBE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15418.34 Da        Isoelectric Point: 4.7118

>T108106 WP_114058221.1 NZ_CP030862:6703805-6704227 [Streptomyces globosus]
VNAALYLIDTSALARFMRNDAEQYGWDQAAAAGLIATCPVTELEFFYSARSAADRARGIEDMRLLFGWVPVDDRAYDRAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHCDHDFDCIAAVTGQPVQWYGPEGRK

Download         Length: 423 bp

>T108106 NZ_CP030862:6703805-6704227 [Streptomyces globosus]
GTGAACGCGGCGCTCTACCTGATCGACACCAGCGCGCTCGCCCGCTTCATGCGGAACGACGCGGAGCAGTACGGCTGGGA
CCAGGCGGCAGCCGCCGGCCTGATCGCCACGTGCCCCGTCACGGAGCTGGAGTTCTTCTACAGCGCCCGGTCGGCAGCCG
ACCGGGCACGCGGCATTGAGGACATGCGGTTGCTCTTCGGCTGGGTTCCCGTCGACGACCGCGCCTACGACCGCGCCTGG
CAGGTCCAGGAGGCCCTCACCAAGCAAGGCAAGCACCGCAGCGCAGGTGCGGTCGACCTCGTCGTCGCAGCGACTGCCGA
GCTGCAGGGGCTCACCCTCCTGCACTGTGACCACGACTTCGACTGCATCGCCGCAGTAACCGGCCAGCCCGTTCAGTGGT
ACGGCCCTGAGGGCCGTAAGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8067.13 Da        Isoelectric Point: 8.6590

>AT108106 WP_114058220.1 NZ_CP030862:6703593-6703808 [Streptomyces globosus]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGSFDLTLFEDKRNYRR

Download         Length: 216 bp

>AT108106 NZ_CP030862:6703593-6703808 [Streptomyces globosus]
ATGAGTCGTACGGTGATCGACCTCGATGACGAACTGGTCGCGGACGTGGCCAAGGCTCTGGGGACCAGCACCAAGAAGGA
GACGGTCAACACCGCCTTGCGCGAGGTGCTGGAGAACAGGCGGCGCGCGCTGGCCCTGACCCGCCTGCGCGCCGCGGCCG
ACGAGGGCTCATTCGATCTGACGCTCTTCGAGGACAAGCGGAACTACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References