Detailed information of TA system TA108106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 6703593..6704227
• Replicon: chromosome
• Accession: NZ_CP030862
• Organism: Streptomyces globosus strain LZH-48

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C0216_RS29800
• Protein ID: WP_114058221.1
• Coordinates: 6703805..6704227 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C0216_RS29795
• Protein ID: WP_114058220.1
• Coordinates: 6703593..6703808 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0216_RS29765	6698658..6700847	-	2190	WP_114058217.1	DNA polymerase III subunit gamma and tau	-
C0216_RS29780	6701370..6702329	+	960	WP_114058218.1	HNH endonuclease	-
C0216_RS29785	6702304..6702731	-	428	Protein_5833	type II toxin-antitoxin system VapC family toxin	-
C0216_RS29790	6702728..6703003	-	276	WP_114058219.1	hypothetical protein	-
C0216_RS29795	6703593..6703808	+	216	WP_114058220.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
C0216_RS29800	6703805..6704227	+	423	WP_114058221.1	PIN domain nuclease	Toxin
C0216_RS29805	6704680..6707133	+	2454	WP_114058222.1	helicase-associated domain-containing protein	-
C0216_RS33650	6707406..6707630	+	225	WP_162793317.1	hypothetical protein	-
C0216_RS29820	6707882..6708616	-	735	WP_114058223.1	helix-turn-helix domain-containing protein	-
C0216_RS29825	6708654..6709073	-	420	WP_114058224.1	TOBE domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-49)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15418.34 Da
• Isoelectric Point: 4.7118

>T108106 WP_114058221.1 NZ_CP030862:6703805-6704227 [Streptomyces globosus]
VNAALYLIDTSALARFMRNDAEQYGWDQAAAAGLIATCPVTELEFFYSARSAADRARGIEDMRLLFGWVPVDDRAYDRAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHCDHDFDCIAAVTGQPVQWYGPEGRK

Nucleotide

• Length: 423 bp

>T108106 NZ_CP030862:6703805-6704227 [Streptomyces globosus]
GTGAACGCGGCGCTCTACCTGATCGACACCAGCGCGCTCGCCCGCTTCATGCGGAACGACGCGGAGCAGTACGGCTGGGA
CCAGGCGGCAGCCGCCGGCCTGATCGCCACGTGCCCCGTCACGGAGCTGGAGTTCTTCTACAGCGCCCGGTCGGCAGCCG
ACCGGGCACGCGGCATTGAGGACATGCGGTTGCTCTTCGGCTGGGTTCCCGTCGACGACCGCGCCTACGACCGCGCCTGG
CAGGTCCAGGAGGCCCTCACCAAGCAAGGCAAGCACCGCAGCGCAGGTGCGGTCGACCTCGTCGTCGCAGCGACTGCCGA
GCTGCAGGGGCTCACCCTCCTGCACTGTGACCACGACTTCGACTGCATCGCCGCAGTAACCGGCCAGCCCGTTCAGTGGT
ACGGCCCTGAGGGCCGTAAGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8067.13 Da
• Isoelectric Point: 8.6590

>AT108106 WP_114058220.1 NZ_CP030862:6703593-6703808 [Streptomyces globosus]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGSFDLTLFEDKRNYRR

Nucleotide

• Length: 216 bp

>AT108106 NZ_CP030862:6703593-6703808 [Streptomyces globosus]
ATGAGTCGTACGGTGATCGACCTCGATGACGAACTGGTCGCGGACGTGGCCAAGGCTCTGGGGACCAGCACCAAGAAGGA
GACGGTCAACACCGCCTTGCGCGAGGTGCTGGAGAACAGGCGGCGCGCGCTGGCCCTGACCCGCCTGCGCGCCGCGGCCG
ACGAGGGCTCATTCGATCTGACGCTCTTCGAGGACAAGCGGAACTACCGGCGGTGA