Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 6037757..6038289 Replicon chromosome
Accession NZ_CP030862
Organism Streptomyces globosus strain LZH-48

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C0216_RS26840 Protein ID WP_114057742.1
Coordinates 6038026..6038289 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C0216_RS26835 Protein ID WP_114057741.1
Coordinates 6037757..6038029 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0216_RS26820 6033805..6035175 - 1371 WP_114057738.1 NarK/NasA family nitrate transporter -
C0216_RS26825 6035273..6036247 - 975 WP_114057739.1 LysR family transcriptional regulator -
C0216_RS26830 6036332..6037702 + 1371 WP_114057740.1 MFS transporter -
C0216_RS26835 6037757..6038029 + 273 WP_114057741.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C0216_RS26840 6038026..6038289 + 264 WP_114057742.1 Txe/YoeB family addiction module toxin Toxin
C0216_RS26850 6038940..6039425 - 486 WP_114057743.1 SsrA-binding protein SmpB -
C0216_RS26855 6039445..6040653 - 1209 WP_114057744.1 PDZ domain-containing protein -
C0216_RS26860 6040721..6041653 - 933 WP_114057745.1 permease-like cell division protein FtsX -
C0216_RS26865 6041673..6042362 - 690 WP_114057746.1 cell division ATP-binding protein FtsE -
C0216_RS26870 6042587..6042778 + 192 WP_114057747.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10310.78 Da        Isoelectric Point: 10.0550

>T108105 WP_114057742.1 NZ_CP030862:6038026-6038289 [Streptomyces globosus]
VRSIHFDPAAWEDFLFWLGADRKMAKRITRLIGEIQRSPFTGIGKPEPLKGDLTGYWSRRIDDEHRLAYRADDKEVKILK
ARYRYSD

Download         Length: 264 bp

>T108105 NZ_CP030862:6038026-6038289 [Streptomyces globosus]
GTGAGGAGTATCCACTTCGACCCGGCAGCCTGGGAGGACTTCCTCTTCTGGCTGGGGGCGGACCGGAAGATGGCGAAGCG
CATCACCCGCCTGATCGGCGAAATCCAGCGGTCTCCCTTCACGGGGATCGGGAAGCCCGAACCGCTCAAGGGCGACCTGA
CCGGCTATTGGTCCCGCAGGATCGACGACGAGCACCGCCTCGCCTACCGGGCCGACGACAAGGAAGTGAAGATCCTCAAG
GCCCGGTACCGCTACTCCGACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9918.12 Da        Isoelectric Point: 4.6412

>AT108105 WP_114057741.1 NZ_CP030862:6037757-6038029 [Streptomyces globosus]
VPISASEARKTLFPLIERVNNDHTPVRISSKSGDAVLMSADDYDAWQETVYLLRSPANARRLMEAVERDRAGTATVAKSM
EELQALAGEE

Download         Length: 273 bp

>AT108105 NZ_CP030862:6037757-6038029 [Streptomyces globosus]
GTGCCTATCAGTGCGAGCGAAGCCCGCAAGACCCTGTTCCCCCTCATCGAGCGCGTCAACAACGACCACACGCCCGTCCG
GATCAGCTCCAAGAGCGGGGACGCGGTCCTGATGTCCGCGGACGACTACGACGCCTGGCAGGAAACGGTGTACCTCCTGC
GCTCGCCGGCGAATGCCCGGCGACTCATGGAGGCCGTGGAACGGGACCGGGCCGGTACGGCCACCGTCGCCAAGAGCATG
GAAGAGCTTCAGGCGCTGGCCGGTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References