Detailed information of TA system TA108104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 910202..910727
• Replicon: chromosome
• Accession: NZ_CP030862
• Organism: Streptomyces globosus strain LZH-48

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C0216_RS04385
• Protein ID: WP_099130288.1
• Coordinates: 910202..910465 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C0216_RS04390
• Protein ID: WP_114053981.1
• Coordinates: 910458..910727 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0216_RS04365	906498..907505	+	1008	WP_114053977.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
C0216_RS04370	907527..908276	+	750	WP_114053978.1	ROK family protein	-
C0216_RS04375	908313..908843	-	531	WP_114053979.1	hypothetical protein	-
C0216_RS04380	908979..910067	+	1089	WP_114053980.1	redox-regulated ATPase YchF	-
C0216_RS04385	910202..910465	-	264	WP_099130288.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C0216_RS04390	910458..910727	-	270	WP_114053981.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C0216_RS04395	911173..912183	-	1011	WP_114053982.1	SMP-30/gluconolactonase/LRE family protein	-
C0216_RS04400	912261..912698	+	438	WP_174250342.1	MarR family transcriptional regulator	-
C0216_RS04405	913196..914242	+	1047	WP_114058448.1	hypothetical protein	-
C0216_RS04410	914441..915550	+	1110	WP_114053983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-56)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10112.59 Da
• Isoelectric Point: 8.5042

>T108104 WP_099130288.1 NZ_CP030862:c910465-910202 [Streptomyces globosus]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVIWVVHVGH
RSTVYET

Nucleotide

• Length: 264 bp

>T108104 NZ_CP030862:c910465-910202 [Streptomyces globosus]
GTGAGTGAGTACCGAACCGTCTTCCGCCCCGAGGCGCAGGCCGAGCTTCGGAAGATCCCCCGCGACATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAGACCGACCCTCTCGGCTTCAACACCACCGCACTCGTGTCACAGCCGGAACGACGCC
GTCTTCGCGTCGGCGACTACCGCGTCGTCTACACGATCGACAACGGCGAGCTGGTGATCTGGGTCGTTCACGTGGGACAC
CGGTCCACCGTTTACGAGACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10287.73 Da
• Isoelectric Point: 4.6265

>AT108104 WP_114053981.1 NZ_CP030862:c910727-910458 [Streptomyces globosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRRYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT108104 NZ_CP030862:c910727-910458 [Streptomyces globosus]
ATGACGCAGCCACTGCCCATAGAGTCCATTCGCGACGTGCGAGCACACCTGGCGGAGGTCGTGGAGCGCGCAGACCGCGA
CGATGTACCCACAGTGATCACGCGCCGAGGCAAGGAAGTCGCGGCCGTCGTCTCCATTGAGGTGCTGCGCAGGTACCAGG
AGTGGGAAGAGCGCGAGATCAATCGGATCATCGACGAGCGCATGGCCAACCCAGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA