Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 462763..463295 Replicon chromosome
Accession NZ_CP030862
Organism Streptomyces globosus strain LZH-48

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C0216_RS02200 Protein ID WP_114053620.1
Coordinates 463041..463295 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C0216_RS02195 Protein ID WP_114053619.1
Coordinates 462763..463044 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0216_RS02170 459309..459983 + 675 WP_162793100.1 hypothetical protein -
C0216_RS33310 460001..460144 + 144 WP_162793101.1 hypothetical protein -
C0216_RS02175 460750..461022 + 273 WP_114053617.1 DUF1876 domain-containing protein -
C0216_RS02180 461082..461324 - 243 WP_114053618.1 DUF397 domain-containing protein -
C0216_RS02185 461321..462145 - 825 WP_174250334.1 helix-turn-helix domain-containing protein -
C0216_RS02190 462285..462782 + 498 WP_114058398.1 ATP-binding protein -
C0216_RS02195 462763..463044 + 282 WP_114053619.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C0216_RS02200 463041..463295 + 255 WP_114053620.1 Txe/YoeB family addiction module toxin Toxin
C0216_RS02205 463391..464197 - 807 WP_114058399.1 VOC family protein -
C0216_RS02210 464670..464759 - 90 Protein_430 general secretion pathway protein GspM -
C0216_RS02215 465217..465825 - 609 WP_114053621.1 NAD(P)H-dependent oxidoreductase -
C0216_RS02220 465983..467776 - 1794 WP_114053622.1 arginine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10104.52 Da        Isoelectric Point: 10.2335

>T108103 WP_114053620.1 NZ_CP030862:463041-463295 [Streptomyces globosus]
VKVVFSGRAWEQYTYWATADPKILKRINRLISEIRRTPFEGTGKPEPLKENLSGWWSRRITDEHRLVYRIQDQAVEVAQV
RYHY

Download         Length: 255 bp

>T108103 NZ_CP030862:463041-463295 [Streptomyces globosus]
GTGAAAGTTGTCTTCTCGGGCCGGGCATGGGAGCAGTACACGTACTGGGCAACTGCCGACCCGAAGATCCTCAAGCGGAT
CAACCGCTTGATCAGCGAAATCCGGCGTACACCCTTCGAAGGCACTGGGAAGCCGGAGCCGCTCAAGGAGAACCTGTCGG
GCTGGTGGTCTCGGCGGATCACCGACGAGCACCGGCTGGTGTACCGGATCCAGGACCAAGCAGTGGAGGTCGCACAGGTC
CGGTACCACTACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10492.60 Da        Isoelectric Point: 4.1523

>AT108103 WP_114053619.1 NZ_CP030862:462763-463044 [Streptomyces globosus]
MSMSANEARQRFYPLIRQVNEDHVPIEVTSREHGDVVIMSAEDFRSWQETVYLLRSPRNAQILMESIAELDAGQGQAREL
ISVDDEEEAGSAA

Download         Length: 282 bp

>AT108103 NZ_CP030862:462763-463044 [Streptomyces globosus]
ATGTCGATGTCAGCCAATGAGGCCCGTCAGCGCTTCTATCCGCTGATCCGGCAGGTCAACGAAGACCACGTGCCCATAGA
GGTCACGTCCCGGGAGCACGGTGACGTGGTGATCATGTCGGCTGAAGACTTCCGCTCTTGGCAGGAAACGGTCTATCTCC
TGCGCTCGCCGCGAAACGCGCAGATCCTGATGGAATCGATCGCAGAGCTGGATGCCGGACAAGGCCAGGCCAGAGAGCTG
ATCAGCGTCGACGACGAGGAAGAAGCCGGGTCCGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References