Detailed information of TA system TA108103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 462763..463295
• Replicon: chromosome
• Accession: NZ_CP030862
• Organism: Streptomyces globosus strain LZH-48

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C0216_RS02200
• Protein ID: WP_114053620.1
• Coordinates: 463041..463295 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C0216_RS02195
• Protein ID: WP_114053619.1
• Coordinates: 462763..463044 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0216_RS02170	459309..459983	+	675	WP_162793100.1	hypothetical protein	-
C0216_RS33310	460001..460144	+	144	WP_162793101.1	hypothetical protein	-
C0216_RS02175	460750..461022	+	273	WP_114053617.1	DUF1876 domain-containing protein	-
C0216_RS02180	461082..461324	-	243	WP_114053618.1	DUF397 domain-containing protein	-
C0216_RS02185	461321..462145	-	825	WP_174250334.1	helix-turn-helix domain-containing protein	-
C0216_RS02190	462285..462782	+	498	WP_114058398.1	ATP-binding protein	-
C0216_RS02195	462763..463044	+	282	WP_114053619.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C0216_RS02200	463041..463295	+	255	WP_114053620.1	Txe/YoeB family addiction module toxin	Toxin
C0216_RS02205	463391..464197	-	807	WP_114058399.1	VOC family protein	-
C0216_RS02210	464670..464759	-	90	Protein_430	general secretion pathway protein GspM	-
C0216_RS02215	465217..465825	-	609	WP_114053621.1	NAD(P)H-dependent oxidoreductase	-
C0216_RS02220	465983..467776	-	1794	WP_114053622.1	arginine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10104.52 Da
• Isoelectric Point: 10.2335

>T108103 WP_114053620.1 NZ_CP030862:463041-463295 [Streptomyces globosus]
VKVVFSGRAWEQYTYWATADPKILKRINRLISEIRRTPFEGTGKPEPLKENLSGWWSRRITDEHRLVYRIQDQAVEVAQV
RYHY

Nucleotide

• Length: 255 bp

>T108103 NZ_CP030862:463041-463295 [Streptomyces globosus]
GTGAAAGTTGTCTTCTCGGGCCGGGCATGGGAGCAGTACACGTACTGGGCAACTGCCGACCCGAAGATCCTCAAGCGGAT
CAACCGCTTGATCAGCGAAATCCGGCGTACACCCTTCGAAGGCACTGGGAAGCCGGAGCCGCTCAAGGAGAACCTGTCGG
GCTGGTGGTCTCGGCGGATCACCGACGAGCACCGGCTGGTGTACCGGATCCAGGACCAAGCAGTGGAGGTCGCACAGGTC
CGGTACCACTACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10492.60 Da
• Isoelectric Point: 4.1523

>AT108103 WP_114053619.1 NZ_CP030862:462763-463044 [Streptomyces globosus]
MSMSANEARQRFYPLIRQVNEDHVPIEVTSREHGDVVIMSAEDFRSWQETVYLLRSPRNAQILMESIAELDAGQGQAREL
ISVDDEEEAGSAA

Nucleotide

• Length: 282 bp

>AT108103 NZ_CP030862:462763-463044 [Streptomyces globosus]
ATGTCGATGTCAGCCAATGAGGCCCGTCAGCGCTTCTATCCGCTGATCCGGCAGGTCAACGAAGACCACGTGCCCATAGA
GGTCACGTCCCGGGAGCACGGTGACGTGGTGATCATGTCGGCTGAAGACTTCCGCTCTTGGCAGGAAACGGTCTATCTCC
TGCGCTCGCCGCGAAACGCGCAGATCCTGATGGAATCGATCGCAGAGCTGGATGCCGGACAAGGCCAGGCCAGAGAGCTG
ATCAGCGTCGACGACGAGGAAGAAGCCGGGTCCGCCGCGTGA