Detailed information of TA system TA108100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 4162369..4163264
• Replicon: chromosome
• Accession: NZ_CP030861
• Organism: Pseudomonas aeruginosa strain HS9

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A318E8F0
• Locus tag: CWE28_RS19995
• Protein ID: WP_023093160.1
• Coordinates: 4162737..4163264 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A318DY98
• Locus tag: CWE28_RS19990
• Protein ID: WP_023093161.1
• Coordinates: 4162369..4162740 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWE28_RS19960	4157477..4157695	+	219	WP_016446183.1	AlpA family transcriptional regulator	-
CWE28_RS19965	4157736..4158602	+	867	WP_023093165.1	ParA family protein	-
CWE28_RS19970	4158586..4158822	+	237	WP_012584779.1	hypothetical protein	-
CWE28_RS19975	4158815..4160473	+	1659	WP_023093164.1	ParB family protein	-
CWE28_RS19980	4160491..4161051	+	561	WP_023093163.1	DUF2857 domain-containing protein	-
CWE28_RS19985	4161055..4162248	+	1194	WP_023093162.1	hypothetical protein	-
CWE28_RS19990	4162369..4162740	+	372	WP_023093161.1	hypothetical protein	Antitoxin
CWE28_RS19995	4162737..4163264	+	528	WP_023093160.1	RES family NAD+ phosphorylase	Toxin
CWE28_RS20000	4163448..4164236	+	789	WP_023093159.1	TIGR03761 family integrating conjugative element protein	-
CWE28_RS20005	4164233..4164781	+	549	WP_023093158.1	DUF3158 family protein	-
CWE28_RS20010	4164778..4165161	+	384	WP_004362284.1	single-stranded DNA-binding protein	-
CWE28_RS20015	4165455..4167470	+	2016	WP_023093157.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4131755..4169074	37319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19831.28 Da
• Isoelectric Point: 5.2440

>T108100 WP_023093160.1 NZ_CP030861:4162737-4163264 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Nucleotide

• Length: 528 bp

>T108100 NZ_CP030861:4162737-4163264 [Pseudomonas aeruginosa]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGCGCGCACACCCCGCAGTGGGCCAGCCGGCCAACCAGCGG
CGCTGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGCGACCG
CGCTACGCGAATACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCATTGCGCGAGCTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAACCTTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTTCACATCGAGCCGCCCACTTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13358.05 Da
• Isoelectric Point: 6.0705

>AT108100 WP_023093161.1 NZ_CP030861:4162369-4162740 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Nucleotide

• Length: 372 bp

>AT108100 NZ_CP030861:4162369-4162740 [Pseudomonas aeruginosa]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAGGCCGCGCTTCGTGACCTGATGCGGGTGCTATCGGCCGCCTCGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATCCCGACGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Structures

Toxin

• AlphaFold DB: A0A318E8F0

Antitoxin

• AlphaFold DB: A0A318DY98