Detailed information of TA system TA108098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2388285..2388790
• Replicon: chromosome
• Accession: NZ_CP030861
• Organism: Pseudomonas aeruginosa strain HS9

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CWE28_RS11745
• Protein ID: WP_023114790.1
• Coordinates: 2388509..2388790 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: CWE28_RS11740
• Protein ID: WP_003083775.1
• Coordinates: 2388285..2388512 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWE28_RS11715	2383303..2384796	+	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
CWE28_RS11720	2384965..2386392	+	1428	WP_003083784.1	GABA permease	-
CWE28_RS11725	2386474..2386815	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
CWE28_RS11730	2386888..2387388	-	501	WP_003101228.1	LEA type 2 family protein	-
CWE28_RS11735	2387489..2388109	+	621	WP_003101226.1	hypothetical protein	-
CWE28_RS11740	2388285..2388512	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
CWE28_RS11745	2388509..2388790	+	282	WP_023114790.1	type II toxin-antitoxin system toxin ParE	Toxin
CWE28_RS11750	2389090..2389998	+	909	WP_003083769.1	LysR family transcriptional regulator	-
CWE28_RS11755	2390030..2390416	-	387	WP_014602345.1	aegerolysin family protein	-
CWE28_RS11760	2390620..2391353	-	734	Protein_2275	GntR family transcriptional regulator	-
CWE28_RS11765	2391454..2392140	-	687	WP_003083762.1	FadR family transcriptional regulator	-
CWE28_RS11770	2392189..2393538	-	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10464.21 Da
• Isoelectric Point: 10.0014

>T108098 WP_023114790.1 NZ_CP030861:2388509-2388790 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Nucleotide

• Length: 282 bp

>T108098 NZ_CP030861:2388509-2388790 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAAGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT108098 WP_003083775.1 NZ_CP030861:2388285-2388512 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT108098 NZ_CP030861:2388285-2388512 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9