Detailed information of TA system TA108094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3878339..3878935
• Replicon: chromosome
• Accession: NZ_CP030850
• Organism: Runella sp. HYN0085

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DR864_RS16220
• Protein ID: WP_114067969.1
• Coordinates: 3878561..3878935 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DR864_RS16215
• Protein ID: WP_114070315.1
• Coordinates: 3878339..3878548 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR864_RS16215	3878339..3878548	+	210	WP_114070315.1	DUF2281 domain-containing protein	Antitoxin
DR864_RS16220	3878561..3878935	+	375	WP_114067969.1	type II toxin-antitoxin system VapC family toxin	Toxin
DR864_RS29860	3879537..3880235	+	699	WP_162793890.1	histidine kinase	-
DR864_RS16230	3880239..3880919	+	681	WP_114067971.1	LytTR family DNA-binding domain-containing protein	-
DR864_RS16235	3880982..3882607	-	1626	WP_114067972.1	ATP-binding cassette domain-containing protein	-
DR864_RS16240	3883097..3883360	-	264	WP_114067973.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (3-124)

Antitoxin

• Domain of unknown function DUF2281 (7-68)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14503.19 Da
• Isoelectric Point: 6.9775

>T108094 WP_114067969.1 NZ_CP030850:3878561-3878935 [Runella sp. HYN0085]
MYLLDTHTLLWYLEENAQLSPKVKKLIEHRICFVHIASFWEIAIKVSIGKLALTYTIDQMIAQLRKEAITILPISEKAIE
VVKTLPLHHRDPFDRLLIAEAITQNYILLSIDIQIDPYPVQRIW

Nucleotide

• Length: 375 bp

>T108094 NZ_CP030850:3878561-3878935 [Runella sp. HYN0085]
ATGTATTTATTGGACACGCATACTTTGTTGTGGTATTTGGAAGAAAATGCTCAGTTATCCCCCAAAGTCAAGAAGTTAAT
AGAACACCGAATTTGCTTCGTTCACATCGCTTCTTTTTGGGAAATAGCCATAAAGGTTTCCATTGGCAAGCTTGCTCTTA
CATATACCATTGACCAGATGATAGCTCAGTTACGAAAAGAAGCCATTACGATTTTACCAATTTCCGAAAAAGCCATTGAA
GTAGTAAAAACCCTGCCGCTCCATCATCGTGACCCATTCGACAGGCTCTTGATTGCAGAGGCCATCACTCAAAACTATAT
TCTGCTGAGTATTGATATACAAATAGACCCTTATCCTGTTCAAAGGATTTGGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7910.15 Da
• Isoelectric Point: 9.4004

>AT108094 WP_114070315.1 NZ_CP030850:3878339-3878548 [Runella sp. HYN0085]
MATDQLLLKEFNKLPASLQQEVLDFVGYLSSKYKTKRSVPKRKAGSMKGLVSYISDDFNAPLEDFKEYM

Nucleotide

• Length: 210 bp

>AT108094 NZ_CP030850:3878339-3878548 [Runella sp. HYN0085]
ATGGCAACCGACCAATTGTTATTGAAAGAGTTTAACAAACTGCCCGCTTCTTTACAGCAGGAAGTACTAGACTTTGTTGG
CTATCTTTCTTCTAAGTATAAAACAAAGCGTTCTGTACCCAAACGTAAAGCCGGCAGTATGAAGGGTTTAGTTTCGTATA
TTTCAGACGACTTCAATGCTCCCCTGGAGGATTTCAAAGAGTATATGTAA