Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3595238..3595886 Replicon chromosome
Accession NZ_CP030849
Organism Pandoraea sp. XY-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DRB87_RS16155 Protein ID WP_130026632.1
Coordinates 3595701..3595886 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DRB87_RS16150 Protein ID WP_130026631.1
Coordinates 3595238..3595657 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB87_RS16130 3591101..3591916 - 816 WP_130026627.1 substrate-binding domain-containing protein -
DRB87_RS16135 3592024..3593343 - 1320 WP_130026628.1 MFS transporter -
DRB87_RS16140 3593649..3594575 + 927 WP_130026629.1 LysR family transcriptional regulator -
DRB87_RS16145 3594711..3595148 + 438 WP_130026630.1 hypothetical protein -
DRB87_RS16150 3595238..3595657 - 420 WP_130026631.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DRB87_RS16155 3595701..3595886 - 186 WP_130026632.1 type II toxin-antitoxin system HicA family toxin Toxin
DRB87_RS16160 3596128..3597315 - 1188 WP_130026633.1 alpha-hydroxy-acid oxidizing protein -
DRB87_RS16165 3597381..3597854 - 474 WP_017235024.1 Lrp/AsnC family transcriptional regulator -
DRB87_RS16170 3598056..3598805 - 750 WP_130026634.1 CerR family C-terminal domain-containing protein -
DRB87_RS16175 3598908..3600143 + 1236 WP_130026635.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7175.19 Da        Isoelectric Point: 11.5152

>T108092 WP_130026632.1 NZ_CP030849:c3595886-3595701 [Pandoraea sp. XY-2]
MKYSEFRRWRRREGATFEQHRAGSSHFRVTLNGRSTVFPDHGAKEMGRALVEAIKKQLDLK

Download         Length: 186 bp

>T108092 NZ_CP030849:c3595886-3595701 [Pandoraea sp. XY-2]
ATGAAGTACAGCGAATTCCGAAGGTGGCGTCGGCGAGAGGGCGCGACATTCGAGCAGCACCGTGCCGGATCCAGTCACTT
TCGAGTCACGCTCAATGGGCGCTCGACGGTATTCCCGGATCATGGTGCCAAGGAGATGGGACGCGCACTGGTGGAAGCCA
TCAAGAAGCAGCTCGATCTGAAATAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15580.17 Da        Isoelectric Point: 9.9093

>AT108092 WP_130026631.1 NZ_CP030849:c3595657-3595238 [Pandoraea sp. XY-2]
MLTYPITLKRDTNDTLLVTFPDVPEAITVGENEAHAREQALEALEAALEFYFAQKRPIPWPSRAKRGQATITLPIMASIK
VLLANEMIAQNVRKAELARRMHVNQVQVDRLLKLGYASRLDAVESAFAVLGKRLEVRAV

Download         Length: 420 bp

>AT108092 NZ_CP030849:c3595657-3595238 [Pandoraea sp. XY-2]
ATGTTGACCTATCCCATTACGCTCAAGCGCGACACGAACGACACGTTGCTGGTCACGTTCCCGGACGTGCCGGAAGCGAT
TACCGTCGGCGAGAACGAGGCGCACGCGCGTGAGCAAGCGCTTGAAGCGCTTGAGGCGGCGCTGGAGTTTTACTTTGCTC
AGAAGCGGCCGATCCCGTGGCCGTCCCGTGCGAAGCGCGGGCAGGCCACGATCACGTTGCCCATCATGGCGTCGATCAAG
GTGCTGCTGGCGAACGAGATGATCGCGCAGAACGTGCGAAAGGCCGAGTTGGCCCGGCGTATGCACGTCAATCAGGTGCA
GGTGGATCGGTTATTGAAGCTTGGCTATGCGTCTCGCCTCGACGCGGTGGAGAGCGCCTTTGCCGTGTTGGGCAAGCGGC
TGGAAGTTCGCGCGGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References