Detailed information of TA system TA108088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 263179..263791
• Replicon: chromosome
• Accession: NZ_CP030845
• Organism: Streptococcus agalactiae strain S73

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: DSN71_RS01600
• Protein ID: WP_000384860.1
• Coordinates: 263179..263514 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: DSN71_RS01605
• Protein ID: WP_000259017.1
• Coordinates: 263504..263791 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSN71_RS01570	258377..259018	+	642	WP_000591144.1	hypothetical protein	-
DSN71_RS01580	259318..260193	+	876	WP_000421240.1	hypothetical protein	-
DSN71_RS01585	260229..260663	+	435	WP_001220479.1	hypothetical protein	-
DSN71_RS01590	260980..262236	+	1257	WP_000122836.1	plasmid recombination protein	-
DSN71_RS01595	262404..262874	+	471	WP_000130119.1	hypothetical protein	-
DSN71_RS01600	263179..263514	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DSN71_RS01605	263504..263791	-	288	WP_000259017.1	hypothetical protein	Antitoxin
DSN71_RS01610	264298..264588	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
DSN71_RS01615	264690..265058	+	369	WP_001882138.1	hypothetical protein	-
DSN71_RS01620	265096..265656	+	561	WP_001865562.1	hypothetical protein	-
DSN71_RS01625	265629..266309	+	681	WP_113792441.1	hypothetical protein	-
DSN71_RS01630	266294..266680	+	387	WP_000259069.1	hypothetical protein	-
DSN71_RS01635	266714..266995	+	282	WP_017647916.1	hypothetical protein	-
DSN71_RS01655	267838..268698	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	255210..264065	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T108088 WP_000384860.1 NZ_CP030845:c263514-263179 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T108088 NZ_CP030845:c263514-263179 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT108088 WP_000259017.1 NZ_CP030845:c263791-263504 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT108088 NZ_CP030845:c263791-263504 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6