Detailed information of TA system TA108076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 37442..37967
• Replicon: plasmid p2017K-0021
• Accession: NZ_CP030796
• Organism: Salmonella enterica strain 2017K-0021

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: DSA03_RS24445
• Protein ID: WP_001159863.1
• Coordinates: 37662..37967 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: DSA03_RS24440
• Protein ID: WP_000813641.1
• Coordinates: 37442..37660 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSA03_RS24405	32455..32689	+	235	Protein_44	polysaccharide deacetylase	-
DSA03_RS24410	33056..33442	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
DSA03_RS24415	33495..33656	+	162	WP_015059604.1	hypothetical protein	-
DSA03_RS24420	33983..34972	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
DSA03_RS24425	35466..35761	-	296	Protein_48	cytoplasmic protein	-
DSA03_RS24430	35881..36111	+	231	WP_001057493.1	hypothetical protein	-
DSA03_RS24435	36245..36766	-	522	WP_077681952.1	hypothetical protein	-
DSA03_RS24440	37442..37660	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
DSA03_RS24445	37662..37967	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
DSA03_RS24450	37969..38259	+	291	WP_001266176.1	hypothetical protein	-
DSA03_RS24455	38256..38777	+	522	WP_000198608.1	hypothetical protein	-
DSA03_RS24460	38812..39594	+	783	WP_000082169.1	site-specific integrase	-
DSA03_RS24465	39603..40315	+	713	Protein_56	EAL domain-containing protein	-
DSA03_RS24470	40319..40828	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
DSA03_RS24475	40822..41307	+	486	WP_000905606.1	membrane protein	-
DSA03_RS24480	41584..41871	-	288	WP_071530243.1	hypothetical protein	-
DSA03_RS24485	42027..42587	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59371	59371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T108076 WP_001159863.1 NZ_CP030796:37662-37967 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T108076 NZ_CP030796:37662-37967 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT108076 WP_000813641.1 NZ_CP030796:37442-37660 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT108076 NZ_CP030796:37442-37660 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6