Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 17975..18567 Replicon plasmid pMCR-1-CTSe
Accession NZ_CP030795
Organism Salmonella enterica strain 2017K-0021

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag DSA03_RS24060 Protein ID WP_000520549.1
Coordinates 18319..18567 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag DSA03_RS24055 Protein ID WP_000681613.1
Coordinates 17975..18322 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSA03_RS24020 13980..14252 - 273 WP_001328551.1 TrbC/VirB2 family protein -
DSA03_RS24025 14320..14940 - 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
DSA03_RS24030 15296..15511 - 216 WP_000760375.1 EexN family lipoprotein -
DSA03_RS24035 15508..15801 - 294 WP_060598542.1 LuxR family transcriptional regulator -
DSA03_RS24040 15878..17107 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
DSA03_RS24045 17111..17614 - 504 WP_000781813.1 hypothetical protein -
DSA03_RS24055 17975..18322 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DSA03_RS24060 18319..18567 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
DSA03_RS24065 18872..19222 - 351 WP_000854259.1 hypothetical protein -
DSA03_RS24070 19313..19612 - 300 WP_000650309.1 hypothetical protein -
DSA03_RS24080 20066..20293 - 228 WP_000801440.1 hypothetical protein -
DSA03_RS24085 20280..20531 - 252 WP_001230707.1 hypothetical protein -
DSA03_RS24090 20528..21070 - 543 WP_001083906.1 hypothetical protein -
DSA03_RS24095 21175..21690 - 516 WP_001025395.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33304 33304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 12233.67 Da        Isoelectric Point: 5.5500

>T108074 WP_000520549.1 NZ_CP030795:c18567-18319 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Download         Length: 249 bp

>T108074 NZ_CP030795:c18567-18319 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTT

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 17090.50 Da        Isoelectric Point: 5.5500

>AT108074 WP_000681613.1 NZ_CP030795:c18322-17975 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 348 bp

>AT108074 NZ_CP030795:c18322-17975 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References